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COLO 800Homo sapiens (Human)Cancer cell line

Also known as: Colorado 800, COLO800, COLO #800, COLO-800

🤖 AI SummaryBased on 10 publications

Quick Overview

Human melanoma cell line for cancer research

Detailed Summary

COLO 800 is a human melanoma cell line derived from a primary tumor. It is widely used in cancer research to study the molecular mechanisms of melanoma, including genetic and epigenetic alterations, and their impact on tumor progression and therapeutic responses. The cell line has been characterized for its genetic profile, including mutations in key oncogenes and tumor suppressor genes, and is utilized in studies related to drug sensitivity, immune evasion, and cancer biology. COLO 800 is also employed in investigations of cell cycle regulation, apoptosis, and the role of specific signaling pathways in melanoma development.

Research Applications

Cancer researchMolecular mechanisms of melanomaGenetic and epigenetic alterationsDrug sensitivity studiesImmune evasion mechanismsCell cycle regulationApoptosis studiesSignaling pathway analysis

Key Characteristics

Human melanoma cell linePrimary tumor originGenetic profiling data availableUsed in drug response studiesInvestigated for immune evasionStudied in cancer biology

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1135
Species	Homo sapiens (Human)
Tissue Source	Hypodermis[UBERON:UBERON_0002072]

Donor Information

Age	14
Age Category	Pediatric
Sex	Male

Disease Information

Disease	Cutaneous melanoma
Lineage	Skin
Subtype	Cutaneous Melanoma
OncoTree Code	SKCM

DepMap Information

Source Type	ATCC
Source ID	ACH-000401_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Cys135Arg (c.403T>C)	Heterozygous	-	Unknown
MutationSimple	TERT	c.1-124C>T (c.228C>T) (C228T)	Unspecified	In promoter	from parent cell line Hep-G2
MutationSimple	CDK4	p.Arg24Cys (c.69_70CC>AT)	Unspecified	-	PubMed=23851445
MutationSimple	BRAF	p.Val600Glu (c.1799T>A)	Unspecified	-	PubMed=26214590

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

10

D13S317

11,13

D16S539

11

D18S51

13,14

D19S433

14

D21S11

29,30

D2S1338

19

D3S1358

18

D5S818

11

D7S820

10,11

D8S1179

14,15

FGA

23

Penta D

11,13

Penta E

7

TH01

6

TPOX

11

vWA

16,20

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14 ARF and RARbeta signaling.

Borg A., Pawelec G., Guldberg P.

Mol. Cancer Res. 11:1166-1178(2013).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

High frequency of homozygosity of the HLA region in melanoma cell lines reveals a pattern compatible with extensive loss of heterozygosity.

Garrido F.

Cancer Immunol. Immunother. 54:141-148(2005).

Mutations of the BRAF gene in human cancer.";

Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.

Nature 417:949-954(2002).

Immunocytochemical analysis of cell lines derived from solid tumors.

Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.

J. Histochem. Cytochem. 49:1369-1378(2001).

Short tandem repeat profiling provides an international reference standard for human cell lines.

Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.

Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001).

Protein B61 as a new growth factor: expression of B61 and up-regulation of its receptor epithelial cell kinase during melanoma progression.

Toso R.J., Herlyn M., Bennett D.C.

Cancer Res. 55:2528-2532(1995).