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COLO 829Homo sapiens (Human)Cancer cell line

Also known as: Colorado 829, Colo829, COLO829, COLO #829, Colo 829, Colo-829, COLO-829

🤖 AI SummaryBased on 14 publications

Quick Overview

Human melanoma cell line with known BRAF mutations and genomic instability.

Detailed Summary

COLO 829 is a human melanoma cell line derived from a metastatic lesion. It is characterized by a hypermutated genome with numerous somatic mutations, including a BRAF V600E mutation, which is a key driver in melanoma pathogenesis. The cell line has been extensively studied for its genomic alterations, including large-scale copy number variations and structural rearrangements. COLO 829 is widely used in cancer research for understanding tumor biology, drug development, and as a reference for somatic mutation analysis. Its genomic profile has been utilized in creating a comprehensive somatic reference standard for cancer genomics.

Research Applications

Genomic instability studiesSomatic mutation analysisDrug developmentCancer biology research

Key Characteristics

BRAF V600E mutationHypermutated genomeSomatic copy number variationsStructural rearrangements
Generated on 6/16/2025

Basic Information

Database IDCVCL_1137
SpeciesHomo sapiens (Human)
Tissue SourceSkin[UBERON:UBERON_0002097]

Donor Information

Age45
Age CategoryAdult
SexMale
Racecaucasian

Disease Information

DiseaseCutaneous melanoma
LineageSkin
SubtypeCutaneous Melanoma
OncoTree CodeSKCM

DepMap Information

Source TypeATCC
Source IDACH-000644_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleTERTc.228_229CC>TT (-124/-125CC>TT)UnspecifiedIn promoterPubMed=23348503
MutationSimplePTENc.493_634del142Homozygous-from parent cell line COLO 829
MutationSimpleCDKN2Ap.Ala68Glyfs*51 (c.203_204delCG)Homozygous-from parent cell line COLO 829
MutationSimpleBRAFp.Val600Glu (c.1799T>A)Unspecified-PubMed=26214590

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
11
D10S1248
14
D12S391
20,22
D13S317
11,12
D16S539
13
D18S51
15
D19S433
14,15
D1S1656
11
D21S11
27,29
D22S1045
16
D2S1338
18,26
D2S441
11,11.3
D3S1358
16,18
D5S818
11
D7S820
8,10
D8S1179
13,14
FGA
21,25
Penta D
9,14
Penta E
7,12
TH01
10
TPOX
8,11
vWA
17,19
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOIPubMedPMC

Single-cell sequencing of genomic DNA resolves sub-clonal heterogeneity in a melanoma cell line.

Edwards P.A.W., Carpten J.D., Craig D.W.

Commun. Biol. 3:318.1-318.8(2020).

DOIPubMedPMC

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOIPubMedPMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOIPubMedPMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOIPubMedPMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOIPubMedPMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOIPubMedPMC

A somatic reference standard for cancer genome sequencing.";

Jones S.J.M., Marra M.A., Carpten J.D., Liang W.S.

Sci. Rep. 6:24607-24607(2016).

DOIPubMedPMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOIPubMedPMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOIPubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOIPubMed

Functional profiling of live melanoma samples using a novel automated platform.

Schuchter L.M., Clark D.P.

PLoS ONE 7:E52760-E52760(2012).

DOIPubMedPMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOIPubMedPMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOIPubMedPMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOIPubMedPMC

A comprehensive catalogue of somatic mutations from a human cancer genome.

Campbell P.J., Bentley D.R., Futreal P.A., Stratton M.R.

Nature 463:191-196(2010).

DOIPubMedPMC

HER3 is a determinant for poor prognosis in melanoma.";

Wild P.J., Hutterer M., Meyer S., Dummer R., Moch H., Ullrich A.

Clin. Cancer Res. 14:5188-5197(2008).

DOIPubMed

High-resolution analysis of DNA copy number using oligonucleotide microarrays.

Weber B., Shapero M.H., Wooster R.

Genome Res. 14:287-295(2004).

DOIPubMedPMC

Mutations of the BRAF gene in human cancer.";

Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.

Nature 417:949-954(2002).

DOIPubMed

Protein B61 as a new growth factor: expression of B61 and up-regulation of its receptor epithelial cell kinase during melanoma progression.

Toso R.J., Herlyn M., Bennett D.C.

Cancer Res. 55:2528-2532(1995).

PubMed

Web Resources

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