COR-L23Homo sapiens (Human)Cancer cell line

Also known as: L23/P, COR-L23/P, COR-L23P, CORL23, COR123

🤖 AI SummaryBased on 10 publications

Quick Overview

Human small cell lung cancer cell line with potential for drug resistance studies.

Detailed Summary

COR-L23 is a human small cell lung cancer cell line established from a patient with lung cancer. It is part of a panel of cell lines used in cancer research, particularly in studies related to drug resistance and chemotherapy sensitivity. The cell line has been utilized in investigations into the mechanisms of cisplatin resistance and the role of specific genes such as MDR1, MRP1, and MRP2 in drug efflux. Additionally, COR-L23 has been involved in studies examining the efficacy of liposomal formulations of cytostatic agents, showing potential for overcoming resistance in enterohepatic tumors. The cell line is also part of the Cancer Cell Line Encyclopedia (CCLE) and has been used in genomic and pharmacological profiling to identify biomarkers for drug response.

Research Applications

Drug resistance studiesChemotherapy sensitivityGenomic profilingPharmacological screening

Key Characteristics

Cisplatin resistanceExpression of MDR1, MRP1, and MRP2Liposomal drug delivery studiesInvolvement in CCLE

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1139
Species	Homo sapiens (Human)
Tissue Source	Pleural effusion[UBERON:UBERON_0000175]

Donor Information

Age	62
Age Category	Adult
Sex	Male
Race	caucasian

Disease Information

Disease	Lung large cell carcinoma
Lineage	Lung
Subtype	Large Cell Lung Carcinoma
OncoTree Code	LCLC

DepMap Information

Source Type	ECACC
Source ID	ACH-000662_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	KRAS	p.Gly12Val (c.35G>T)	Heterozygous	Acquired	Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

10,11

D16S539

11,13

D18S51

13,16

D19S433

D21S11

31.2

D2S1338

23,26

D3S1358

D5S818

10,12

D7S820

D8S1179

10,13

FGA

Penta D

Penta E

12,20

TH01

TPOX

8,11

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Differential effector engagement by oncogenic KRAS.";

McCormick F.

Cell Rep. 22:1889-1902(2018).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Usefulness of liposomes loaded with cytostatic bile acid derivatives to circumvent chemotherapy resistance of enterohepatic tumors.

Marin J.J.G.

Mol. Pharmacol. 63:742-750(2003).

DOI PubMed

Mutations of the BRAF gene in human cancer.";

Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.

Nature 417:949-954(2002).

DOI PubMed

A 190-kilodalton protein overexpressed in non-P-glycoprotein-containing multidrug-resistant cells and its relationship to the MRP gene.

Twentyman P.R.

J. Natl. Cancer Inst. 86:110-117(1994).

DOI PubMed

Oncogene amplification and chromosomal abnormalities in small cell lung cancer.

Ibson J.M., Waters J.J., Twentyman P.R., Bleehen N.M., Rabbitts P.H.

J. Cell. Biochem. 33:267-288(1987).

DOI PubMed

Establishment and characterisation of cell lines from patients with lung cancer (predominantly small cell carcinoma).

Watson J.V., Johnson N., Reeve J.G., Bleehen N.M.

Br. J. Cancer 52:495-504(1985).

DOI PubMed PMC