COR-L279Homo sapiens (Human)Cancer cell line

Also known as: LuCL4, CORL279, COR L279

🤖 AI SummaryBased on 9 publications

Quick Overview

Human cancer cell line with known genetic alterations and potential for drug response studies.

Detailed Summary

COR-L279 is a human cancer cell line derived from an unspecified tissue type. It is part of a large panel of cancer cell lines used in genomic and pharmacological studies. Research has identified specific genetic alterations, including mutations and chromosomal abnormalities, which may contribute to its tumorigenic properties. These alterations include homozygous deletions and gene fusions, which are common in various cancers and can influence drug sensitivity and resistance. The cell line is utilized in studies aimed at understanding the molecular mechanisms of cancer and developing targeted therapies. Its genetic profile makes it a valuable resource for investigating the relationship between genetic changes and therapeutic outcomes.

Research Applications

Genomic and pharmacological studiesInvestigation of genetic alterations and their impact on drug responseMolecular mechanisms of cancerDevelopment of targeted therapies

Key Characteristics

Homozygous deletionsGene fusionsPotential for drug sensitivity studies

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1140
Species	Homo sapiens (Human)
Tissue Source	Lymph node[UBERON:UBERON_0000029]

Donor Information

Age	63
Age Category	Adult
Sex	Male

Disease Information

Disease	Small cell lung cancer
Lineage	Lung
Subtype	Small Cell Lung Cancer
OncoTree Code	SCLC

DepMap Information

Source Type	ECACC
Source ID	ACH-000257_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	c.376-4_384del13	Homozygous	-	Unknown, Unknown
MutationSimple	EP300	c.1623-45_1623-41 (c.2822-43del3)	Heterozygous	-	PubMed=10700188

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

D13S317

D16S539

D18S51

13,16

D21S11

30,32.2

D3S1358

D5S818

D7S820

9,10

D8S1179

FGA

Penta D

14,15

Penta E

TH01

6,9.3

TPOX

9,11

vWA

16,17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.

Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.

OncoImmunology 3:e954893.1-e954893.12(2014).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Chromosomal alterations in small cell lung cancer revealed by multicolour fluorescence in situ hybridization.

Cawkwell L.

Int. J. Cancer 102:230-236(2002).

DOI PubMed

Mutations truncating the EP300 acetylase in human cancers.";

Delhanty J.D.A., Ponder B.A.J., Kouzarides T., Caldas C.

Nat. Genet. 24:300-303(2000).

DOI PubMed

Sensitivity to novel platinum compounds of panels of human lung cancer cell lines with acquired and inherent resistance to cisplatin.

Twentyman P.R., Wright K.A., Mistry P., Kelland L.R., Murrer B.A.

Cancer Res. 52:5674-5680(1992).

PubMed