COR-L88Homo sapiens (Human)Cancer cell line

Also known as: CorL88, CORL88, Cor L88

🤖 AI SummaryBased on 11 publications

Quick Overview

Human lung cancer cell line with known genetic alterations and potential for drug response studies.

Detailed Summary

COR-L88 is a human lung cancer cell line derived from a patient with small cell lung carcinoma. It is characterized by specific genetic alterations, including amplifications of the c-myc gene and deletions on chromosome 3p. These alterations are associated with tumor progression and may influence the response to therapeutic agents. The cell line is used in research to study the molecular mechanisms of cancer and to evaluate the efficacy of potential anticancer drugs. Its genetic profile makes it a valuable model for understanding the biology of small cell lung cancer and for developing targeted therapies.

Research Applications

Genetic and molecular profilingDrug response studiesTumor biology research

Key Characteristics

Amplification of c-myc geneDeletion on chromosome 3pPotential for studying tumor progression
Generated on 6/16/2025

Basic Information

Database IDCVCL_1141
SpeciesHomo sapiens (Human)
Tissue SourcePleural effusion[UBERON:UBERON_0000175]

Donor Information

Age55
Age CategoryAdult
SexMale
Racecaucasian

Disease Information

DiseaseSmall cell lung cancer
LineageLung
SubtypeSmall Cell Lung Cancer
OncoTree CodeSCLC

DepMap Information

Source TypeECACC
Source IDACH-000508_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleTP53p.Val157Phe (c.469G>T)Homozygous-Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
10
D13S317
11
D16S539
11,12
D18S51
16,17
D21S11
30
D3S1358
17
D5S818
13
D7S820
9
D8S1179
9,13
FGA
19,20
Penta D
9
Penta E
14
TH01
7
TPOX
8,10
vWA
14,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.

Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.

OncoImmunology 3:e954893.1-e954893.12(2014).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Two prognostically significant subtypes of high-grade lung neuroendocrine tumours independent of small-cell and large-cell neuroendocrine carcinomas identified by gene expression profiles.

Nakagawa K., Nomura H., Ishikawa Y.

Lancet 363:775-781(2004).

Chromosomal alterations in small cell lung cancer revealed by multicolour fluorescence in situ hybridization.

Cawkwell L.

Int. J. Cancer 102:230-236(2002).

Oncogene amplification and chromosomal abnormalities in small cell lung cancer.

Ibson J.M., Waters J.J., Twentyman P.R., Bleehen N.M., Rabbitts P.H.

J. Cell. Biochem. 33:267-288(1987).

Establishment and characterisation of cell lines from patients with lung cancer (predominantly small cell carcinoma).

Watson J.V., Johnson N., Reeve J.G., Bleehen N.M.

Br. J. Cancer 52:495-504(1985).