CW-2Homo sapiens (Human)Cancer cell line

Also known as: CW2

🤖 AI SummaryBased on 7 publications

Quick Overview

Human cancer cell line for research on genetic and molecular mechanisms.

Detailed Summary

The CW-2 cell line is a human-derived cancer cell line used in various research applications. It is characterized by its genetic and molecular profiles, which make it suitable for studying cancer biology and drug responses. The cell line has been utilized in studies involving transcriptomic and genomic analyses to understand cancer progression and therapeutic strategies. Research on this cell line has contributed to the identification of gene fusions, mutations, and other genomic alterations that are relevant to cancer development and treatment. The CW-2 cell line is part of larger panels of cancer cell lines that are used to model different aspects of cancer biology, providing insights into the heterogeneity of cancer and the development of targeted therapies.

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1151
Species	Homo sapiens (Human)
Tissue Source	Colon[UBERON:UBERON_0001155]

Donor Information

Age	55
Age Category	Adult
Sex	Female
Subtype Features	MSI

Disease Information

Disease	Colon adenocarcinoma
Lineage	Bowel
Subtype	Colon Adenocarcinoma
OncoTree Code	COAD

DepMap Information

Source Type	RIKEN
Source ID	ACH-000998_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Pro47Pro (c.141G>A)	Heterozygous	-	Unknown, Unknown
MutationSimple	KRAS	p.Pro140His (c.419C>A)	Heterozygous	-	Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

10,11,14

D12S391

19,20

D13S317

9,11

D16S539

D18S51

12,13

D19S433

12,14.2

D21S11

D2S1338

D3S1358

16,17

D5S818

11,12,13

D7S820

10,12,13

D8S1179

15,17

FGA

21,22

Penta D

10,11

Penta E

11,14

TH01

7,8

TPOX

8,12

vWA

18,21

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Genomic determinants of protein abundance variation in colorectal cancer cells.

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Choudhary J.S.

Cell Rep. 20:2201-2214(2017).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

5-fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency.

Bracht K., Nicholls A.M., Liu Y., Bodmer W.F.

Br. J. Cancer 103:340-346(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC