D283 MedHomo sapiens (Human)Cancer cell line

Also known as: H283, Med 283, D283, D-283, D283-Med, D283Med, D283MED, D-283MED, D-283 Med-C, D-283 Med, D283_Med, D283-MED, D283 MED, D283 MR (Occasionally.)

🤖 AI SummaryBased on 12 publications

Quick Overview

Human medulloblastoma cell line with potential for research in cancer biology and therapy.

Detailed Summary

The D283 Med cell line is derived from a human medulloblastoma and is used in cancer research. It exhibits characteristics such as the ability to form spheroids in vitro and has been utilized in studies related to tumor growth and therapeutic responses. This cell line is valuable for investigating the molecular mechanisms underlying medulloblastoma and for testing potential treatments. Research involving D283 Med has contributed to understanding the role of specific genes and pathways in tumor progression and has been used in preclinical models to evaluate drug efficacy.

Research Applications

Cancer biology researchTherapeutic drug testingMolecular mechanism studies

Key Characteristics

In vitro spheroid formationPotential for preclinical modelsGene expression studies

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1155
Species	Homo sapiens (Human)
Tissue Source	Ascites[UBERON:UBERON_0007795]

Donor Information

Age	6
Age Category	Pediatric
Sex	Male
Race	caucasian
Subtype Features	MYC_Exp

Disease Information

Disease	Medulloblastoma
Lineage	CNS/Brain
Subtype	Medulloblastoma
OncoTree Code	MBL

DepMap Information

Source Type	ATCC
Source ID	ACH-000055_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

9,12

D13S317

8,10

D16S539

D18S51

16,18

D19S433

13,14

D21S11

28,30.2

D2S1338

17,23

D3S1358

D5S818

D7S820

D8S1179

12,13

FGA

20,23

Penta D

9,13

Penta E

7,10

TH01

TPOX

8,11

vWA

16,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Human medulloblastoma cell lines: investigating on cancer stem cell-like phenotype.

Pothier A., Merla C., Mancuso M.

Cancers (Basel) 12:226.1-226.14(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Data on the number and frequency of scientific literature citations for established medulloblastoma cell lines.

Ivanov D.P., Walker D.A., Coyle B., Grabowska A.M.

Data Brief 9:696-698(2016).

DOI PubMed PMC

In vitro models of medulloblastoma: choosing the right tool for the job.

Ivanov D.P., Coyle B., Walker D.A., Grabowska A.M.

J. Biotechnol. 236:10-25(2016).

DOI PubMed

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

PID1 (NYGGF4), a new growth-inhibitory gene in embryonal brain tumors and gliomas.

Pfister S.M., Kool M., Sposto R., Asgharzadeh S.

Clin. Cancer Res. 20:827-836(2014).

DOI PubMed PMC

BET bromodomain inhibition of MYC-amplified medulloblastoma.";

Bradner J.E., Beroukhim R., Cho Y.-J.

Clin. Cancer Res. 20:912-925(2014).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

miR-34a confers chemosensitivity through modulation of MAGE-A and p53 in medulloblastoma.

Pomeroy S.L., Cho Y.-J.

Neuro-oncol. 13:165-175(2011).

DOI PubMed PMC

Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma.

Marquez V.E., Cho Y.-J., Pomeroy S.L.

Neuro-oncol. 12:1244-1256(2010).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Hypercalcaemia in relapsed medulloblastoma 8 years post-diagnosis; evidence to support PTHrP production by medulloblastoma cells.

Hale J., Cheetham T.D.

Horm. Res. 66:268-272(2006).

DOI PubMed

Protein profiles of medulloblastoma cell lines DAOY and D283: identification of tumor-related proteins and principles.

Peyrl A., Krapfenbauer K., Slavc I., Yang J.-W., Strobel T., Lubec G.

Proteomics 3:1781-1800(2003).

DOI PubMed

Establishment and characterization of the human medulloblastoma cell line and transplantable xenograft D283 Med.

Wikstrand C.J., Halperin E.C., Bigner D.D.

J. Neuropathol. Exp. Neurol. 44:592-605(1985).

DOI PubMed

A rapidly dividing human medulloblastoma cell line (D283 MED) expresses all three neurofilament subunits.

Trojanowski J.Q., Friedman H.S., Burger P.C., Bigner D.D.

Am. J. Pathol. 126:358-363(1987).

PubMed PMC

Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts.

Bigner S.H., Friedman H.S., Vogelstein B., Oakes W.J., Bigner D.D.

Cancer Res. 50:2347-2350(1990).

PubMed

Medulloblastoma cell-substrate interaction in vitro.";

Wikstrand C.J., Friedman H.S., Bigner D.D.

Invasion Metastasis 11:310-324(1991).

PubMed

Brain tumors.";

Ali-Osman F.

(In book chapter) Human cell culture. Vol. 2. Cancer cell lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.167-184; Kluwer Academic Publishers; New York; USA (1999).

DOI