DaoyHomo sapiens (Human)Cancer cell line
Also known as: D324, D-324MED, D324 MED, D-324 Med, D324 Med, DAOY
Quick Overview
Human medulloblastoma cell line for cancer research.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_1167 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Brain, posterior fossa[UBERON:UBERON_0008788] |
Donor Information
| Age | 4 |
|---|---|
| Age Category | Pediatric |
| Sex | Male |
| Race | caucasian |
| Subtype Features | MYC_No |
Disease Information
| Disease | Medulloblastoma |
|---|---|
| Lineage | CNS/Brain |
| Subtype | Medulloblastoma |
| OncoTree Code | MBL |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000211_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Cys242Phe (c.725G>T) | Unspecified | - | PubMed=1394225 |
| MutationSimple | TERT | c.1-124C>T (c.228C>T) (C228T) | Unspecified | In promoter | from parent cell line Hep-G2 |
| Gene deletion | CDKN2A | - | Homozygous | Possible | PubMed=26870271 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
Sellers W.R., Gygi S.P.
Cell 180:387-402.e16(2020).
Human medulloblastoma cell lines: investigating on cancer stem cell-like phenotype.
Pothier A., Merla C., Mancuso M.
Cancers (Basel) 12:226.1-226.14(2020).
Biological characterization of the UW402, UW473, ONS-76 and DAOY pediatric medulloblastoma cell lines.
de Oliveira Menezes C.C.B., Palma P.V.B., Fontes A.M.
Cytotechnology 71:893-903(2019).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Top-down proteomic characterization of DAOY medulloblastoma tumor cell line.
Desiderio C.
EuPA Open Proteom. 12:13-21(2016).
Data on the number and frequency of scientific literature citations for established medulloblastoma cell lines.
Ivanov D.P., Walker D.A., Coyle B., Grabowska A.M.
Data Brief 9:696-698(2016).
In vitro models of medulloblastoma: choosing the right tool for the job.
Ivanov D.P., Coyle B., Walker D.A., Grabowska A.M.
J. Biotechnol. 236:10-25(2016).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
BET bromodomain inhibition of MYC-amplified medulloblastoma.";
Bradner J.E., Beroukhim R., Cho Y.-J.
Clin. Cancer Res. 20:912-925(2014).
EphB2 activity plays a pivotal role in pediatric medulloblastoma cell adhesion and invasion.
Kamps W.A., Diks S.H., Peppelenbosch M.P., de Bont E.S.J.M.
Neuro-oncol. 14:1125-1135(2012).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
MDM2 antagonism by nutlin-3 induces death in human medulloblastoma cells.
Ghassemifar S., Mendrysa S.M.
Neurosci. Lett. 513:106-110(2012).
Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma.
Marquez V.E., Cho Y.-J., Pomeroy S.L.
Neuro-oncol. 12:1244-1256(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
Flow cytometric characterization of the DAOY medulloblastoma cell line for the cancer stem-like phenotype.
Srivastava V.K., Nalbantoglu J.
Cytometry A 73:940-948(2008).
Protein profiles of medulloblastoma cell lines DAOY and D283: identification of tumor-related proteins and principles.
Peyrl A., Krapfenbauer K., Slavc I., Yang J.-W., Strobel T., Lubec G.
Proteomics 3:1781-1800(2003).
Establishment of a human medulloblastoma cell line and its heterotransplantation into nude mice.
Jacobsen P.F., Jenkyn D.J., Papadimitriou J.M.
J. Neuropathol. Exp. Neurol. 44:472-485(1985).
Medulloblastoma cell-substrate interaction in vitro.";
Wikstrand C.J., Friedman H.S., Bigner D.D.
Invasion Metastasis 11:310-324(1991).
Human glioma cell lines.";
Nister M., Westermark B.
(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.17-42; Academic Press; New York; USA (1994).
Brain tumors.";
Ali-Osman F.
(In book chapter) Human cell culture. Vol. 2. Cancer cell lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.167-184; Kluwer Academic Publishers; New York; USA (1999).