DBTRG-05MGHomo sapiens (Human)Cancer cell line

Also known as: DBTRG, DBTRG05MG, DBTRG.05MG

🤖 AI SummaryBased on 8 publications

Quick Overview

Human glioblastoma cell line with known genetic alterations

Detailed Summary

DBTRG-05MG is a human glioblastoma cell line derived from a brain tumor. It is commonly used in cancer research to study tumor biology, drug sensitivity, and genetic mutations. This cell line has been characterized in multiple studies, including the Cancer Cell Line Encyclopedia (CCLE) and other genomic profiling efforts. Research on DBTRG-05MG has contributed to understanding the genetic basis of glioblastoma and identifying potential therapeutic targets. The cell line is part of a large panel of cancer cell lines used for high-throughput screening and functional genomics studies.

Research Applications

Cancer biology researchDrug sensitivity screeningGenomic profilingFunctional genomics studies

Key Characteristics

Human glioblastoma cell lineUsed in high-throughput screeningPart of the Cancer Cell Line Encyclopedia (CCLE)Characterized in multiple genomic studies

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1169
Species	Homo sapiens (Human)
Tissue Source	Brain[UBERON:UBERON_0000955]

Donor Information

Age	59
Age Category	Adult
Sex	Female
Race	caucasian

Disease Information

Disease	Anaplastic astrocytoma
Lineage	CNS/Brain
Subtype	Glioblastoma
OncoTree Code	GB

DepMap Information

Source Type	ATCC
Source ID	ACH-000863_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	BRAF	p.Val600Glu (c.1799T>A)	Unspecified	-	PubMed=26214590

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

10,11

D13S317

D16S539

10,12

D18S51

12,16

D19S433

D21S11

29,31.2

D2S1338

23,24

D3S1358

14,15

D5S818

12,13

D7S820

D8S1179

FGA

22,25

Penta D

9,13

Penta E

TH01

7,8

TPOX

vWA

15,16

Gene Expression Profile

Gene expression levels and statistical distribution

Loading cohorts...

Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Immunocytochemical analysis of cell lines derived from solid tumors.

Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.

J. Histochem. Cytochem. 49:1369-1378(2001).

DOI PubMed

Brain tumors.";

Ali-Osman F.

(In book chapter) Human cell culture. Vol. 2. Cancer cell lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.167-184; Kluwer Academic Publishers; New York; USA (1999).

DOI