Detroit 562Homo sapiens (Human)Cancer cell line
Also known as: D562, Det562, Det. 562, Det 562, DETROIT562, Detroit562, Detroit-562, DETROIT 562
Quick Overview
Human pharyngeal cancer cell line for studying infection and cancer mechanisms.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_1171 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Pleural effusion[UBERON:UBERON_0000175] |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Female |
| Race | caucasian |
Disease Information
| Disease | Squamous cell carcinoma of the oral cavity |
|---|---|
| Lineage | Head and Neck |
| Subtype | Oropharynx Squamous Cell Carcinoma |
| OncoTree Code | OPHSC |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000207_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg175His (c.524G>A) | Unspecified | Somatic mutation acquired during proliferation | from parent cell line YCC-3 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
Sellers W.R., Gygi S.P.
Cell 180:387-402.e16(2020).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Nature 568:511-516(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
The Detroit 562 pharyngeal immortalized cell line model for the assessment of infectivity of pathogenic Neisseria sp.
Kibble E.A., Sarkar-Tyson M., Coombs G.W., Kahler C.M.
Methods Mol. Biol. 1969:123-133(2019).
Epithelial-mesenchymal crosstalk induces radioresistance in HNSCC cells.
Riechelmann H., Dudas J., Skvortsova I.-I.
Oncotarget 9:3641-3652(2018).
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Oncotarget 8:86369-86383(2017).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
JunB promotes cell invasion, migration and distant metastasis of head and neck squamous cell carcinoma.
Ito Y., Myers J.N., Oridate N.
J. Exp. Clin. Cancer Res. 35:6.1-6.12(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies.
Zaida M., Delic N.C., Samuels Y., Lyons J.G., Gutkind J.S.
Oncotarget 5:8906-8923(2014).
Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability.
Symer D.E., Gillison M.L.
Genome Res. 24:185-199(2014).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Clin. Cancer Res. 17:7248-7264(2011).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
The galanin signaling cascade is a candidate pathway regulating oncogenesis in human squamous cell carcinoma.
Sasaki K., Hanazawa T., Okamoto Y., Hata A.
Genes Chromosomes Cancer 48:132-142(2009).
Signaling pathways required for matrix metalloproteinase-9 induction by betacellulin in head-and-neck squamous carcinoma cells.
O-Charoenrat P., Wongkajornsilp A., Rhys-Evans P.H., Eccles S.A.
Int. J. Cancer 111:174-183(2004).
A synthetic matrix metalloproteinase inhibitor prevents squamous carcinoma cell proliferation by interfering with epidermal growth factor receptor autocrine loops.
O-Charoenrat P., Rhys-Evans P.H., Eccles S.A.
Int. J. Cancer 100:527-533(2002).
Overexpression of epidermal growth factor receptor in human head and neck squamous carcinoma cell lines correlates with matrix metalloproteinase-9 expression and in vitro invasion.
Eccles S.A.
Int. J. Cancer 86:307-317(2000).
A molecular approach to the identification and individualization of human and animal cells in culture: isozyme and allozyme genetic signatures.
O'Brien S.J., Shannon J.E., Gail M.H.
In Vitro 16:119-135(1980).
Relationship between karyotype of tissue culture lines and tumorigenicity in nude mice.
Gershwin M.E., Lentz D., Owens R.B.
Exp. Cell Biol. 52:361-370(1984).
Cell culture quality control by rapid isoenzymatic characterization.
Halton D.M., Peterson W.D. Jr., Hukku B.
In Vitro 19:16-24(1983).
Polymorphic enzyme analysis of cultured human tumor cell lines.";
Dracopoli N.C., Fogh J.
J. Natl. Cancer Inst. 70:469-476(1983).
Glucose-6-phosphate dehydrogenase isoenzymes in human cell cultures determined by sucrose-agar gel and cellulose acetate zymograms.
Peterson W.D. Jr., Stulberg C.S., Swanborg N.K., Robinson A.R.
Proc. Soc. Exp. Biol. Med. 128:772-776(1968).
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
Fogh J., Wright W.C., Loveless J.D.
J. Natl. Cancer Inst. 58:209-214(1977).
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
Fogh J., Fogh J.M., Orfeo T.
J. Natl. Cancer Inst. 59:221-226(1977).
Tissue typing of cells in culture. III. HLA antigens of established human cell lines. Attempts at typing by the mixed hemadsorption technique.
Espmark J.A., Ahlqvist-Roth L., Sarne L., Persson A.
Tissue Antigens 11:279-286(1978).
Head and neck tumor cell lines.";
Carey T.E.
(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York; USA (1994).
Chromosome abnormalities in human tumor cells in culture.";
Biedler J.L.
(In book chapter) Human tumor cells in vitro; Fogh J. (eds.); pp.359-394; Springer; New York; USA (1975).