DMS 114Homo sapiens (Human)Cancer cell line
Also known as: Darmouth Medical School 114, DMS114, DMS-114
DMS114
Quick Overview
Human small cell lung cancer cell line with known genetic alterations.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_1174 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lung[UBERON:UBERON_0002048] |
Donor Information
| Age | 68 |
|---|---|
| Age Category | Adult |
| Sex | Male |
| Race | caucasian |
Disease Information
| Disease | Thoracic SMARCA4-deficient undifferentiated tumor |
|---|---|
| Lineage | Lung |
| Subtype | SMARCA4-deficient undifferentiated tumor |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000530_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg213Ter (c.637C>T) | Unspecified | - | Unknown |
| MutationUnexplicit | PARD3B | Ex2-14del | Homozygous | - | PubMed=20215515 |
| MutationSimple | SMARCA4 | p.Glu1310Ter (c.3928G>T) | Homozygous | - | Unknown |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Molecular and pathologic characterization of YAP1-expressing small cell lung cancer cell lines leads to reclassification as SMARCA4-deficient malignancies.
Burr M.L., Sutherland K.D.
Clin. Cancer Res. 30:1846-1858(2024).
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
Sellers W.R., Gygi S.P.
Cell 180:387-402.e16(2020).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.
Heymach J.V.
Cancer Discov. 2:798-811(2012).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
JFCR39, a panel of 39 human cancer cell lines, and its application in the discovery and development of anticancer drugs.
Kong D.-X., Yamori T.
Bioorg. Med. Chem. 20:1947-1951(2012).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target.
Tomoda H., Yamori T., Tsuruo T.
J. Natl. Cancer Inst. 97:765-777(2005).
The role of RAD51 in etoposide (VP16) resistance in small cell lung cancer.
Hansen L.T., Lundin C., Spang-Thomsen M., Petersen L.N., Helleday T.
Int. J. Cancer 105:472-479(2003).
In vitro invasion of small-cell lung cancer cell lines correlates with expression of epidermal growth factor receptor.
Poulsen H.S.
Br. J. Cancer 78:631-640(1998).
Cellular radiosensitivity of small-cell lung cancer cell lines.";
Krarup M., Poulsen H.S., Spang-Thomsen M.
Int. J. Radiat. Oncol. Biol. Phys. 38:191-196(1997).
Resistance mechanisms determining the in vitro sensitivity to paclitaxel of tumour cells cultured from patients with ovarian cancer.
van Zijl P.L.
Eur. J. Cancer 31A:230-237(1995).
Isolation and growth characteristics of continuous cell lines from small-cell carcinoma of the lung.
Noll W.W., Cate C.C., Maurer L.H.
Cancer 45:906-918(1980).
Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.
Fine D.L., Abbott B.J., Mayo J.G., Shoemaker R.H., Boyd M.R.
Cancer Res. 48:589-601(1988).
Growth characteristics and heterogeneity of small cell carcinoma of the lung.
Vindelov L.L., Hansen H.H., Spang-Thomsen M.
Recent Results Cancer Res. 97:47-54(1985).
Metabolic activation of 4-ipomeanol in human lung, primary pulmonary carcinomas, and established human pulmonary carcinoma cell lines.
Adelberg S., Czerwinski M.J., McMahon N.A., Eggleston J.C., Boyd M.R.
J. Natl. Cancer Inst. 82:1420-1426(1990).