DMS 153Homo sapiens (Human)Cancer cell line

Also known as: Darmouth Medical School 153, DMS153, DMS-153

🤖 AI SummaryBased on 8 publications

Quick Overview

Human small cell lung cancer cell line with known genetic and molecular characteristics.

Detailed Summary

DMS 153 is a human small cell lung cancer (SCLC) cell line that has been extensively studied for its genetic and molecular characteristics. It is known for its expression of the epidermal growth factor receptor (EGFR) and its sensitivity to various therapeutic agents. Research has shown that DMS 153 exhibits specific patterns of gene expression and mutations that contribute to its tumorigenic potential. The cell line has been used in studies investigating the role of growth hormone-releasing hormone (GHRH) antagonists and bombesin (BN)/gastrin-releasing peptide (GRP) antagonists in inhibiting tumor growth. Additionally, DMS 153 has been utilized in studies examining the effects of PARP1 inhibition and the role of p53 mutations in cancer progression. The cell line is also part of large-scale genomic and pharmacological studies, such as the Cancer Cell Line Encyclopedia (CCLE), which provides comprehensive data on drug sensitivity and genetic profiles. These studies have contributed to understanding the mechanisms of drug resistance and the identification of potential therapeutic targets in SCLC.

Research Applications

Drug sensitivity profilingGenomic and molecular characterizationTherapeutic target identificationMechanisms of drug resistanceEGFR and PARP1 signaling pathwaysp53 mutation analysis

Key Characteristics

Expression of EGFRSensitivity to GHRH antagonistsSensitivity to PARP1 inhibitorsPresence of p53 mutationsInvolvement in large-scale genomic studies (CCLE)

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1175
Species	Homo sapiens (Human)
Tissue Source	Liver[UBERON:UBERON_0002107]

Donor Information

Age	44
Age Category	Adult
Sex	Male
Race	caucasian

Disease Information

Disease	Small cell lung cancer
Lineage	Lung
Subtype	Small Cell Lung Cancer
OncoTree Code	SCLC

DepMap Information

Source Type	ATCC
Source ID	ACH-000594_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Thr155Pro (c.463A>C)	Unspecified	-	PubMed=12872257

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

12,13

D16S539

12,13

D18S51

16,17

D19S433

12.1,15

D21S11

26.2,30

D2S1338

17,20

D3S1358

14,17

D5S818

D6S1043

11,18

D7S820

8,10

D8S1179

12,14

FGA

Penta D

9,12

Penta E

TH01

7,9.3

TPOX

vWA

14,15

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.

Heymach J.V.

Cancer Discov. 2:798-811(2012).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Inhibition of mutant p53 expression and growth of DMS-153 small cell lung carcinoma by antagonists of growth hormone-releasing hormone and bombesin.

Varga J.L.

Proc. Natl. Acad. Sci. U.S.A. 100:15836-15841(2003).

DOI PubMed PMC

The role of RAD51 in etoposide (VP16) resistance in small cell lung cancer.

Hansen L.T., Lundin C., Spang-Thomsen M., Petersen L.N., Helleday T.

Int. J. Cancer 105:472-479(2003).

DOI PubMed

In vitro invasion of small-cell lung cancer cell lines correlates with expression of epidermal growth factor receptor.

Poulsen H.S.

Br. J. Cancer 78:631-640(1998).

DOI PubMed PMC

Isolation and growth characteristics of continuous cell lines from small-cell carcinoma of the lung.

Noll W.W., Cate C.C., Maurer L.H.

Cancer 45:906-918(1980).

DOI PubMed

Growth characteristics and heterogeneity of small cell carcinoma of the lung.

Vindelov L.L., Hansen H.H., Spang-Thomsen M.

Recent Results Cancer Res. 97:47-54(1985).

DOI PubMed