Back to Cell Types

DMS 273Homo sapiens (Human)Cancer cell line

Also known as: Darmouth Medical School 273, DMS273, DMS-273

🤖 AI SummaryBased on 12 publications

DMS273

Quick Overview

Human cancer cell line with potential for research in cancer biology and drug development.

Detailed Summary

DMS273 is a human cancer cell line derived from an unspecified tissue and disease type. It is part of a large panel of cancer cell lines used in genomic and pharmacological studies. Research on DMS273 has focused on understanding its genetic and molecular characteristics, including mutations, gene expression, and drug sensitivity. The cell line has been utilized in studies related to cancer genomics, drug discovery, and the identification of potential therapeutic targets. Its specific applications include investigations into tumor biology, drug response, and the development of personalized cancer therapies. The cell line is also part of comprehensive datasets such as the Cancer Cell Line Encyclopedia (CCLE) and has been analyzed for its genomic features and therapeutic vulnerabilities.

Research Applications

Cancer genomicsDrug discoveryTherapeutic target identificationPersonalized cancer therapyPharmacological profiling

Key Characteristics

Part of large cancer cell line panelsUsed in genomic and pharmacological studiesAnalyzed for genetic and molecular featuresPotential for drug sensitivity research

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1176
Species	Homo sapiens (Human)
Tissue Source	Pleural effusion[UBERON:UBERON_0000175]

Donor Information

Age	50
Age Category	Adult
Sex	Female

Disease Information

Disease	Small cell lung cancer
Lineage	Lung
Subtype	Small Cell Lung Cancer
OncoTree Code	SCLC

DepMap Information

Source Type	ECACC
Source ID	ACH-000749_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Gly245Cys (c.733G>T)	Heterozygous	Somatic mutation acquired during proliferation	PubMed=18487078, PubMed=16020667, PubMed=15287027, PubMed=12884349, PubMed=1394225
MutationSimple	NPM1	p.Asp173del (c.511_513delGAT)	Heterozygous	-	Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

10,12

D13S317

12,13

D16S539

11

D18S51

12,16

D21S11

28,31

D3S1358

16

D5S818

11,12

D7S820

10,12

D8S1179

12,13

FGA

20

Penta D

9,11

Penta E

13

TH01

9.3

TPOX

10

vWA

15

Gene Expression Profile

Gene expression levels and statistical distribution

Loading cohorts...

Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.

Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.

OncoImmunology 3:e954893.1-e954893.12(2014).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

JFCR39, a panel of 39 human cancer cell lines, and its application in the discovery and development of anticancer drugs.

Kong D.-X., Yamori T.

Bioorg. Med. Chem. 20:1947-1951(2012).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target.

Tomoda H., Yamori T., Tsuruo T.

J. Natl. Cancer Inst. 97:765-777(2005).

The role of RAD51 in etoposide (VP16) resistance in small cell lung cancer.

Hansen L.T., Lundin C., Spang-Thomsen M., Petersen L.N., Helleday T.

Int. J. Cancer 105:472-479(2003).

In vitro invasion of small-cell lung cancer cell lines correlates with expression of epidermal growth factor receptor.

Poulsen H.S.

Br. J. Cancer 78:631-640(1998).

Cellular radiosensitivity of small-cell lung cancer cell lines.";

Krarup M., Poulsen H.S., Spang-Thomsen M.

Int. J. Radiat. Oncol. Biol. Phys. 38:191-196(1997).

Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.

Fine D.L., Abbott B.J., Mayo J.G., Shoemaker R.H., Boyd M.R.

Cancer Res. 48:589-601(1988).

Growth characteristics and heterogeneity of small cell carcinoma of the lung.

Vindelov L.L., Hansen H.H., Spang-Thomsen M.

Recent Results Cancer Res. 97:47-54(1985).

Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines.

Gray-Goodrich M., Campbell H., Mayo J.G., Boyd M.R.

J. Natl. Cancer Inst. 83:757-766(1991).