DMS 79Homo sapiens (Human)Cancer cell line
Also known as: Darmouth Medical School 79, DMS79, DMS-79, DMS76 (In text of PubMed 20439192.)
Quick Overview
Human small cell lung cancer cell line with known genetic and molecular characteristics.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
Database ID | CVCL_1178 |
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Species | Homo sapiens (Human) |
Tissue Source | Pleural effusion[UBERON:UBERON_0000175] |
Donor Information
Age | 65 |
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Age Category | Adult |
Sex | Male |
Race | caucasian |
Disease Information
Disease | Small cell lung cancer |
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Lineage | Lung |
Subtype | Small Cell Lung Cancer |
OncoTree Code | SCLC |
DepMap Information
Source Type | ATCC |
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Source ID | ACH-000703_source |
Known Sequence Variations
Type | Gene/Protein | Description | Zygosity | Note | Source |
---|---|---|---|---|---|
MutationSimple | TP53 | p.Arg280Glufs*65 (c.837delG) (p.G279fs) | Unspecified | - | Unknown |
MutationSimple | RB1 | p.Gly801Ter (c.2401G>T) | Homozygous | - | Unknown, Unknown |
MutationSimple | PTPRU | p.Glu442Ter (c.1324G>T) | Heterozygous | - | Unknown, Unknown |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
OncoImmunology 3:e954893.1-e954893.12(2014).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.
Heymach J.V.
Cancer Discov. 2:798-811(2012).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
Integrative genomic analysis of small-cell lung carcinoma reveals correlates of sensitivity to bcl-2 antagonists and uncovers novel chromosomal gains.
Sauter G., Lesniewski R., Semizarov D.
Mol. Cancer Res. 5:331-339(2007).
Two prognostically significant subtypes of high-grade lung neuroendocrine tumours independent of small-cell and large-cell neuroendocrine carcinomas identified by gene expression profiles.
Nakagawa K., Nomura H., Ishikawa Y.
Lancet 363:775-781(2004).
The role of RAD51 in etoposide (VP16) resistance in small cell lung cancer.
Hansen L.T., Lundin C., Spang-Thomsen M., Petersen L.N., Helleday T.
Int. J. Cancer 105:472-479(2003).
In vitro invasion of small-cell lung cancer cell lines correlates with expression of epidermal growth factor receptor.
Poulsen H.S.
Br. J. Cancer 78:631-640(1998).
Glucocorticoid inhibition of ACTH peptides: small cell lung cancer cell lines are more resistant than pituitary corticotroph adenoma cells.
White A.
J. Mol. Endocrinol. 10:25-32(1993).
Isolation and growth characteristics of continuous cell lines from small-cell carcinoma of the lung.
Noll W.W., Cate C.C., Maurer L.H.
Cancer 45:906-918(1980).