DoTc2 4510Homo sapiens (Human)Cancer cell line
Also known as: DoTc2, DOTC24510, DOTC2-4510, DoTc2-4510
🤖 AI SummaryBased on 3 publications
Quick Overview
Human uterine epithelial cell line for cancer research.
Detailed Summary
The DoTc2 4510 cell line is derived from human uterine epithelial cells and is utilized in cancer research. It provides a model for studying the molecular mechanisms underlying uterine cancers. This cell line is valuable for investigating genetic alterations and their implications in tumorigenesis. Research involving this cell line may contribute to understanding the role of specific genes and pathways in cancer progression and therapeutic responses.
Research Applications
Cancer researchMolecular mechanisms of tumorigenesisGenetic alterations in cancer
Key Characteristics
Human uterine epithelial cell lineModel for studying uterine cancersValuable for investigating genetic and molecular pathways in cancer
Generated on 6/16/2025
Basic Information
| Database ID | CVCL_1181 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Uterus, cervix[UBERON:UBERON_0000002] |
Donor Information
| Age Category | Unknown |
|---|---|
| Sex | Female |
Disease Information
| Disease | Cervical carcinoma |
|---|---|
| Lineage | Cervix |
| Subtype | Mixed Cervical Carcinoma |
| OncoTree Code | MCCE |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-001341_source |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
12
D13S317
11
D16S539
12,13
D18S51
14
D21S11
30
D3S1358
16
D5S818
14
D7S820
11,13
D8S1179
13
FGA
22
Penta D
11
Penta E
12
TH01
7
TPOX
8
vWA
16,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).