DV-90Homo sapiens (Human)Cancer cell line

Also known as: DV90

🤖 AI SummaryBased on 6 publications

Quick Overview

DV-90 is a human cancer cell line used in research for studying cancer biology and drug sensitivity.

Detailed Summary

DV-90 is a human cancer cell line derived from unknown tissue and disease origins. It is utilized in cancer research to investigate genetic and molecular mechanisms underlying tumor development and response to therapeutic agents. The cell line is part of large-scale genomic and transcriptomic studies, contributing to the understanding of cancer heterogeneity and the identification of potential biomarkers for drug sensitivity. Research involving DV-90 has been published in several high-impact journals, highlighting its role in advancing cancer research and personalized medicine.

Research Applications

Cancer biology researchDrug sensitivity profilingGenomic and transcriptomic analysisBiomarker discovery

Key Characteristics

Part of large-scale cancer cell line studiesUsed in identifying oncogenic fusions and mutationsContributed to understanding cancer heterogeneity

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1184
Species	Homo sapiens (Human)
Tissue Source	Pleural effusion[UBERON:UBERON_0000175]

Donor Information

Age	50
Age Category	Adult
Sex	Male

Disease Information

Disease	Lung adenocarcinoma
Lineage	Lung
Subtype	Lung Adenocarcinoma
OncoTree Code	LUAD

DepMap Information

Source Type	DSMZ
Source ID	ACH-000925_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	KRAS	p.Gly13Asp (c.38G>A)	Heterozygous	Somatic	from parent cell line MDA-MB-231

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

10,12

D13S317

10,12

D16S539

11,12

D18S51

13,14

D19S433

13,17

D21S11

31,31.2

D2S1338

17,24

D3S1358

13,16

D5S818

11,13

D7S820

11,14

D8S1179

14,16

FGA

22,24

Penta D

9,10

Penta E

10,13

TH01

7,8

TPOX

vWA

14,15

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

Comparative proteome analysis across non-small cell lung cancer cell lines.

Daub H.

J. Proteomics 130:1-10(2016).

DOI PubMed

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Analysis of chromosomal alterations in non-small cell lung cancer by multiplex-FISH, comparative genomic hybridization, and multicolor bar coding.

Petersen I.

Lab. Invest. 80:1031-1041(2000).

DOI PubMed

Biologic characterization of pleural metastases from lung adenocarcinoma: description of the new DV90 cell line.

Ravaioli A.

Tumori 80:378-384(1994).

DOI PubMed