EB2Homo sapiens (Human)Cancer cell line
Also known as: Epstein-Barr-2, EB-2
Quick Overview
EB2 is a human B-cell line derived from Burkitt's lymphoma, used in cancer research.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_1186 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Ovary[UBERON:UBERON_0000992] |
Donor Information
| Age | 7 |
|---|---|
| Age Category | Pediatric |
| Sex | Female |
| Race | black_or_african_american |
Disease Information
| Disease | Burkitt lymphoma |
|---|---|
| Lineage | Lymphoid |
| Subtype | Burkitt Lymphoma |
| OncoTree Code | BL |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-001064_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Gly244Asp (c.731G>A) | Unspecified | - | PubMed=28273451 |
| MutationSimple | ARID1A | p.Gln501Ter (c.1501C>T) | Heterozygous | - | Unknown |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
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Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
The behaviour and morphology of a second tissue culture strain (EB2) of lymphoblasts from Burkitt's lymphoma.
Epstein M.A., Barr Y.M., Achong B.G.
Br. J. Cancer 19:108-115(1965).
Variable IgH chain enhancer activity in Burkitt's lymphomas suggests an additional, direct mechanism of c-myc deregulation.
Jain V.K., Judde J.-G., Max E.E., Magrath I.T.
J. Immunol. 150:5418-5428(1993).
Differences in genetic stability between human cell lines from patients with and without lymphoreticular malignancy.
Povey S., Jeremiah S., Arthur E., Steel M., Klein G.
Ann. Hum. Genet. 44:119-133(1980).
Chromosome studies of 8 in vitro lines of Burkitt's lymphoma.";
Miles C.P., O'Neill F.
Cancer Res. 27:392-402(1967).
Studies with Burkitt's lymphoma.";
Epstein M.A., Barr Y.M., Achong B.G.
Wistar Inst. Symp. Monogr. 4:69-82(1965).
Heterotransplantability of human cell lines derived from leukemia and lymphomas into immunologically tolerant rats.
McComb V.
Cancer 24:211-222(1969).
Genetic studies on human lymphoblastoid lines: isozyme analysis on cell lines from forty-one different individuals and on mutants produced following exposure to a chemical mutagen.
Steel C.M., Blenkinsop C., Evans H.J.
Ann. Hum. Genet. 36:247-266(1973).
The cytogenetics of human B lymphoid malignancy: studies in Burkitt's lymphoma and Epstein-Barr virus-transformed lymphoblastoid cell lines.
Steel C.M., Morten J.E.N., Foster E.
IARC Sci. Publ. 60:265-292(1985).