EC-GI-10Homo sapiens (Human)Cancer cell line

Also known as: EC-GI, ECGI10

🤖 AI SummaryBased on 7 publications

Quick Overview

Human cancer cell line with known HLA type and neo-epitopes for immunotherapy research.

Detailed Summary

EC-GI-10 is a human cancer cell line derived from a squamous cell carcinoma of the esophagus, known for its ability to produce interleukin-1α (IL-1α) and a parathyroid hormone-like factor. This cell line is notable for its role in studying humoral hypercalcemia of malignancy, as it secretes factors that stimulate osteoclastic bone resorption. EC-GI-10 has been used in research to understand the molecular mechanisms of cancer-related hypercalcemia and the role of IL-1α in this process. Additionally, it is part of a comprehensive database that integrates HLA type, predicted neo-epitopes, and virus expression, making it a valuable resource for immunotherapy and cancer research.

Research Applications

Immunotherapy researchCancer-related hypercalcemia studiesHLA typing and neo-epitope predictionVirus detection in cancer cell lines

Key Characteristics

Produces IL-1α and PTH-like factorsAssociated with humoral hypercalcemiaIntegrated HLA and neo-epitope dataExpresses viral sequences

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1187
Species	Homo sapiens (Human)
Tissue Source	Lymph node[UBERON:UBERON_0000029]

Donor Information

Age	65
Age Category	Adult
Sex	Male

Disease Information

Disease	Squamous cell carcinoma of the esophagus
Lineage	Esophagus/Stomach
Subtype	Esophageal Squamous Cell Carcinoma
OncoTree Code	ESCC

DepMap Information

Source Type	RIKEN
Source ID	ACH-000305_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg273Leu (c.818G>T)	Homozygous	Somatic mutation acquired during proliferation	PubMed=31541927, PubMed=23613873, PubMed=15735012
MutationSimple	TP53	p.Tyr234Cys (c.701A>G)	Heterozygous	-	PubMed=27822414

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

10,11

D13S317

D16S539

11,12

D18S51

D21S11

D5S818

D7S820

8,11

D8S1179

9,13

FGA

21,24

TH01

7,9

TPOX

vWA

16,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Short tandem repeat profiling provides an international reference standard for human cell lines.

Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.

Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001).

DOI PubMed PMC

Production of interleukin-1 alpha and a parathyroid hormone-like factor by a squamous cell carcinoma of the esophagus (EC-GI) derived from a patient with hypercalcemia.

Sato K., Fujii Y., Kasono K., Tsushima T., Shizume K.

J. Clin. Endocrinol. Metab. 67:592-601(1988).

DOI PubMed

Establishment of a parathyroid hormone-like factor-producing esophageal carcinoma cell line (EC-GI).

Tsushima T., Shizume K.

Jpn. J. Cancer Res. 78:1044-1048(1987).

DOI PubMed