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ECC10Homo sapiens (Human)Cancer cell line

Also known as: ECC 10, ECC-10

🤖 AI SummaryBased on 5 publications

Quick Overview

ECC10 is a human cancer cell line derived from gastrointestinal carcinoma, used in cancer research.

Detailed Summary

ECC10 is a human cancer cell line established from small-cell gastrointestinal carcinoma, commonly used in cancer research. It exhibits characteristics such as neurosecretory granules and specific growth patterns. The cell line is utilized for studying tumor biology, drug sensitivity, and genetic mutations. ECC10 has been analyzed for its HLA type, gene expression, and potential neo-epitopes, making it a valuable resource for immunotherapy research. Its applications include investigating cancer cell line variability, drug response, and molecular mechanisms of cancer progression.

Research Applications

Cancer researchImmunotherapyDrug sensitivityGenetic mutationsTumor biology

Key Characteristics

Neurosecretory granulesSpecific growth patternsHLA type analysisGene expression profilingNeo-epitope prediction
Generated on 6/16/2025

Basic Information

Database IDCVCL_1188
SpeciesHomo sapiens (Human)
Tissue SourceStomach[UBERON:UBERON_0000945]

Donor Information

Age73
Age CategoryAdult
SexMale

Disease Information

DiseaseGastric small cell carcinoma
LineageEsophagus/Stomach
SubtypeSmall Cell Carcinoma of the Stomach
OncoTree CodeSTSC

DepMap Information

Source TypeRIKEN
Source IDACH-000560_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleRB1p.Gln685Ter (c.2053C>T)Heterozygous-Unknown, Unknown
MutationSimpleERBB2p.Leu755Ser (c.2264T>C)Heterozygous-Unknown, Unknown
MutationSimpleAPCp.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA)Heterozygous-from parent cell line WiDr

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
12,13
D13S317
11
D16S539
11
D5S818
12
D7S820
10,12
TH01
7
TPOX
11
vWA
19
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOIPubMedPMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOIPubMedPMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOIPubMedPMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOIPubMedPMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOIPubMedPMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOIPubMedPMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOIPubMedPMC

Characterization of four new cell lines derived from small-cell gastrointestinal carcinoma.

Kato K., Ichinose H., Nagatsu T.

Int. J. Cancer 54:965-971(1993).

DOIPubMed