ECC12Homo sapiens (Human)Cancer cell line

Also known as: ECC 12, ECC-12

🤖 AI SummaryBased on 5 publications

Quick Overview

ECC12 is a human cancer cell line derived from small-cell gastrointestinal carcinoma, used in cancer research.

Detailed Summary

ECC12 is a human cancer cell line established from small-cell gastrointestinal carcinoma, specifically from a patient with esophageal cancer. It is characterized by its morphological and biochemical features, including the presence of neurosecretory granules and specific enzyme expressions. The cell line has been used in studies related to cancer biology, including investigations into tumor characteristics, drug sensitivity, and genetic mutations. ECC12 is part of the Cancer Cell Line Encyclopedia (CCLE) and has been analyzed for its HLA type, gene expression, and potential neo-epitopes, making it a valuable resource for immunotherapy research. Its use in studies involving small-cell carcinomas and its response to various treatments make it a significant model in cancer research.

Research Applications

Cancer biologyImmunotherapy researchDrug sensitivity studiesGenetic mutation analysis

Key Characteristics

Presence of neurosecretory granulesSpecific enzyme expressions (e.g., CK-BB, NSE)HLA type determinationNeo-epitope prediction

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1189
Species	Homo sapiens (Human)
Tissue Source	Stomach[UBERON:UBERON_0000945]

Donor Information

Age	63
Age Category	Adult
Sex	Male

Disease Information

Disease	Gastric small cell carcinoma
Lineage	Esophagus/Stomach
Subtype	Small Cell Carcinoma of the Stomach
OncoTree Code	STSC

DepMap Information

Source Type	RIKEN
Source ID	ACH-000225_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Val216Met (c.646G>A)	Unspecified	-	Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

D13S317

D16S539

9,11

D5S818

D7S820

10,11

TH01

TPOX

vWA

16,19

Gene Expression Profile

Gene expression levels and statistical distribution

Loading cohorts...

Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Characterization of four new cell lines derived from small-cell gastrointestinal carcinoma.

Kato K., Ichinose H., Nagatsu T.

Int. J. Cancer 54:965-971(1993).

DOI PubMed