EFE-184Homo sapiens (Human)Cancer cell line

Also known as: EFE184

🤖 AI SummaryBased on 6 publications

Quick Overview

Human cancer cell line for research on genetic and drug response studies.

Detailed Summary

EFE-184 is a human cancer cell line derived from an unspecified tissue and disease. It is used in research to study genetic mutations and their impact on drug sensitivity. The cell line is part of large-scale studies aiming to understand the relationship between cancer genomics and therapeutic responses. It has been utilized in projects like the Cancer Cell Line Encyclopedia (CCLE) to analyze genomic data and drug sensitivity profiles. The cell line's characteristics are part of efforts to improve cancer treatment strategies through personalized medicine approaches.

Research Applications

Genomic and drug response studiesCancer genomics and therapeutic response analysisPersonalized medicine research

Key Characteristics

Part of the Cancer Cell Line Encyclopedia (CCLE)Used in studies of drug sensitivity and genetic mutations

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1191
Species	Homo sapiens (Human)
Tissue Source	Ascites[UBERON:UBERON_0007795]

Donor Information

Age	69
Age Category	Adult
Sex	Female
Race	caucasian

Disease Information

Disease	Endometrial carcinoma
Lineage	Uterus
Subtype	Endometrial Carcinoma
OncoTree Code	UCEC

DepMap Information

Source Type	DSMZ
Source ID	ACH-000435_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg282Trp (c.844C>T)	Unspecified	-	PubMed=21173094, PubMed=1373872
MutationNone reported	PTEN	-	-	-	PubMed=20944090

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

10,12

D13S317

D16S539

D18S51

12,18

D19S433

D21S11

30,33.2

D2S1338

18,20

D3S1358

14,17

D5S818

11,13

D7S820

10,11

D8S1179

11,13

FGA

Penta D

10,13

Penta E

TH01

9.3

TPOX

8,11

vWA

15,16

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.

van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.

Nat. Commun. 10:3574.1-3574.11(2019).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors.

Lord C.J., Ashworth A., Reis-Filho J.S.

Sci. Transl. Med. 2:53ra75.1-53ra75.8(2010).

DOI PubMed

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Web Resources

tcpaportal.org