EFO-27Homo sapiens (Human)Cancer cell line

Also known as: EFO27, EFO 27

🤖 AI SummaryBased on 14 publications

Quick Overview

Human ovarian cancer cell line with specific genetic and molecular characteristics.

Detailed Summary

EFO-27 is a human ovarian cancer cell line derived from a solid metastasis of a mucinous papillary adenocarcinoma. It has been extensively studied for its genetic and molecular characteristics, including chromosomal abnormalities and responses to various treatments. Research indicates that EFO-27 exhibits specific karyotypic alterations, including near-tetraploidy and the presence of marker chromosomes. These features make it a valuable model for studying ovarian cancer biology and therapeutic responses. The cell line has been used in studies related to genomic instability, drug sensitivity, and the identification of potential therapeutic targets.

Research Applications

Genomic instability studiesDrug sensitivity testingTherapeutic target identification

Key Characteristics

Near-tetraploid karyotypePresence of marker chromosomesChromosomal abnormalities
Generated on 6/16/2025

Basic Information

Database IDCVCL_1192
SpeciesHomo sapiens (Human)
Tissue SourceOmentum[UBERON:UBERON_0003688]

Donor Information

Age36
Age CategoryAdult
SexFemale

Disease Information

DiseaseMucinous adenocarcinoma of ovary
LineageOvary/Fallopian Tube
SubtypeMucinous Ovarian Cancer
OncoTree CodeMOV

DepMap Information

Source TypeDSMZ
Source IDACH-000936_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleTP53p.Arg273Cys (c.817C>T)Homozygous-PubMed=35933914
MutationSimplePTENp.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA)Heterozygous-Unknown, Unknown, PubMed=25230021

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
9,10,13,14
D13S317
12,13
D16S539
11,13
D18S51
12,18
D19S433
13,14
D21S11
27,30
D2S1338
22,25
D3S1358
14,17
D5S818
11,12
D7S820
8,10
D8S1179
13
FGA
23,26
Penta D
9
Penta E
7,10
TH01
6,8
TPOX
8
vWA
13,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Integrated genomic, epigenomic, and expression analyses of ovarian cancer cell lines.

Velculescu V.E., Scharpf R.B.

Cell Rep. 25:2617-2633(2018).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

Evaluating cell lines as tumour models by comparison of genomic profiles.

Domcke S., Sinha R., Levine D.A., Sander C., Schultz N.

Nat. Commun. 4:2126.1-2126.10(2013).

BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation.

Mills G.B., Hennessy B.T.

Mol. Oncol. 7:567-579(2013).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Identification of microsatellite instability and mismatch repair gene mutations in breast cancer cell lines.

Santibanez-Koref M.F., Schlag P.M., Scherneck S.

Genes Chromosomes Cancer 37:29-35(2003).

Cell lines derived from human ovarian carcinomas: growth stimulation by gonadotropic and steroid hormones.

Simon W.E., Albrecht M., Hansel M., Dietel M., Holzel F.

J. Natl. Cancer Inst. 70:839-845(1983).

Karyotype alterations in human ovarian carcinoma cells during long-term cultivation and nude mouse passage.

Kunzmann R., Holzel F.

Cancer Genet. Cytogenet. 28:201-212(1987).

Web Resources