EPLC-272HHomo sapiens (Human)Cancer cell line

Also known as: EPidermoid Lung Cancer-272H, EPLC272H

🤖 AI SummaryBased on 8 publications

Quick Overview

Human cancer cell line for research on lung cancer and drug sensitivity.

Detailed Summary

EPLC-272H is a human cancer cell line derived from lung tissue, commonly used in cancer research. It is part of a large panel of cell lines used to study the genetic and molecular characteristics of various cancers. This cell line has been utilized in studies focusing on drug sensitivity and resistance, contributing to the understanding of cancer biology and therapeutic strategies. Research on EPLC-272H has provided insights into the mechanisms of cancer progression and the identification of potential therapeutic targets.

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1197
Species	Homo sapiens (Human)

Donor Information

Age	57
Age Category	Adult
Sex	Male
Race	caucasian

Disease Information

Disease	Lung mucoepidermoid carcinoma
Lineage	Lung
Subtype	Lung Squamous Cell Carcinoma
OncoTree Code	LUSC

DepMap Information

Source Type	DSMZ
Source ID	ACH-000585_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Tyr107Ter (c.321C>G)	Homozygous	-	Unknown, Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

12,13

D16S539

11,12

D18S51

D19S433

D21S11

31.2

D2S1338

D3S1358

D5S818

D7S820

8,9

D8S1179

FGA

Penta D

Penta E

11,12

TH01

7,9.3

TPOX

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

Gene-expression data integration to squamous cell lung cancer subtypes reveals drug sensitivity.

Wu D., Pang Y., Wilkerson M.D., Wang D., Hammerman P.S., Liu J.S.

Br. J. Cancer 109:1599-1608(2013).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC