ESS-1Homo sapiens (Human)Cancer cell line

Also known as: Endometrial Stromal Sarcoma-1, ESS1

🤖 AI SummaryBased on 5 publications

Quick Overview

ESS-1 is a human endometrial stromal cell line used in cancer research.

Detailed Summary

ESS-1 is a human endometrial stromal cell line derived from the endometrium. It is used in cancer research to study the molecular mechanisms of endometrial cancer and other related diseases. The cell line is characterized by its ability to grow in culture and maintain the features of the original tissue. Research on ESS-1 has contributed to understanding the genetic and molecular changes associated with endometrial cancer, including the identification of key pathways and potential therapeutic targets. The cell line is also used to evaluate the efficacy of new drugs and treatments for endometrial cancer.

Research Applications

Cancer researchMolecular mechanisms of endometrial cancerDrug efficacy testing

Key Characteristics

Human endometrial stromal cell lineUsed for studying endometrial cancerCapable of in vitro growth

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1205
Species	Homo sapiens (Human)
Tissue Source	Endometrium[UBERON:UBERON_0001295]

Donor Information

Age	76
Age Category	Adult
Sex	Female
Race	caucasian

Disease Information

Disease	Endometrial stromal sarcoma
Lineage	Uterus
Subtype	Endometrial Stromal Sarcoma
OncoTree Code	ESS

DepMap Information

Source Type	DSMZ
Source ID	ACH-000913_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg213Ter (c.637C>T)	Unspecified	-	Unknown
MutationSimple	PTEN	p.Arg142Trp (c.424C>T)	Heterozygous	-	Unknown, Unknown
MutationSimple	PIK3CA	p.Glu545Lys (c.1633G>A)	Heterozygous	-	from parent cell line MCF-7
MutationSimple	FBXW7	p.Glu694Ter (c.2080G>T)	Heterozygous	-	Unknown, Unknown
MutationSimple	FBXW7	p.Arg465Cys (c.1393C>T)	Heterozygous	-	from parent cell line CCRF-CEM

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

10,14

D13S317

8,12

D16S539

12,13

D18S51

14,17

D19S433

13,15

D21S11

D2S1338

20,25

D3S1358

14,15

D5S818

10,12

D7S820

9,11

D8S1179

13,16

FGA

20,21

Penta D

9,12

Penta E

10,18

TH01

7,9

TPOX

vWA

16,17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Characterization of a newly established endometrial stromal sarcoma cell line.

Gunawan B., Braun S., Cortes M.J., Bergmann F., Karl C., Fuzesi L.

Int. J. Cancer 77:424-428(1998).

DOI PubMed

Web Resources

tcpaportal.org