FaDuHomo sapiens (Human)Cancer cell line
Also known as: FaDU, FADU, JHU-SCC-FaDu
Quick Overview
Human hypopharyngeal squamous cell carcinoma cell line used in cancer research.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_1218 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Pharynx, hypopharynx[UBERON:UBERON_0001051] |
Donor Information
| Age | 56 |
|---|---|
| Age Category | Adult |
| Sex | Male |
| Race | caucasian |
Disease Information
| Disease | Hypopharyngeal squamous cell carcinoma |
|---|---|
| Lineage | Head and Neck |
| Subtype | Hypopharynx Squamous Cell Carcinoma |
| OncoTree Code | HPHSC |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000846_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | CDKN2A | c.151-1G>T | Unspecified | Splice acceptor mutation | PubMed=33802339 |
| MutationSimple | FAT1 | p.Lys3277Asnfs*4 (c.9828delG) (p.Gly3276fs) | Heterozygous | - | from parent cell line FaDu |
| MutationSimple | TP53 | c.376-1G>A (p.Tyr126_Lys132del, c.376_396del21) | Unspecified | Splice acceptor mutation | from parent cell line U-1285 |
| MutationSimple | TP53 | p.Arg248Leu (c.743G>T) | Unspecified | - | PubMed=18487078 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Fanconi anemia-isogenic head and neck cancer cell line pairs: a basic and translational science resource.
Smogorzewska A., Monnat R.J. Jr.
Int. J. Cancer 153:183-196(2023).
Head and neck tumor cell lines.";
Carey T.E.
(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York; USA (1994).
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
Fogh J., Fogh J.M., Orfeo T.
J. Natl. Cancer Inst. 59:221-226(1977).
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
Fogh J., Wright W.C., Loveless J.D.
J. Natl. Cancer Inst. 58:209-214(1977).
Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines.
Yee C., Krishnan-Hewlett I., Baker C.C., Schlegel R., Howley P.M.
Am. J. Pathol. 119:361-366(1985).
Multiparametric flow cytometry of human squamous cell carcinoma lines from the head and neck.
Wustrow T.P.U., Raffael A., Valet G.K.
Otolaryngol. Head Neck Surg. 98:552-557(1988).
A new human cell line (FaDu) from a hypopharyngeal carcinoma.";
Rangan S.R.S.
Cancer 29:117-121(1972).
Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis.
Wright W.C., Daniels W.P., Fogh J.
J. Natl. Cancer Inst. 66:239-247(1981).
Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.
Rousset M., Zweibaum A., Fogh J.
Cancer Res. 41:1165-1170(1981).
Amplification and expression of EMS-1 (cortactin) in head and neck squamous cell carcinoma cell lines.
Somers K.D.
Oncogene 12:31-35(1996).
Inhibition of head and neck squamous cell carcinoma growth and invasion by the calcium influx inhibitor carboxyamido-triazole.
Schechter G.L., Spoonster J.R., Kohn E.C., Somers K.D.
Clin. Cancer Res. 3:1915-1921(1997).
Splicing mutations in TP53 in human squamous cell carcinoma lines influence immunohistochemical detection.
Eicheler W., Zips D., Dorfler A., Grenman R., Baumann M.
J. Histochem. Cytochem. 50:197-204(2002).
Phosphoinositide kinase-3 status associated with presence or absence of human papillomavirus in head and neck squamous cell carcinomas.
Yarbrough W.G., Whigham A., Brown B., Roach M., Slebos R.J.C.
Int. J. Radiat. Oncol. Biol. Phys. 69:S98-S101(2007).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
FaDu cell characteristics induced by multidrug resistance.";
Ma J.-K., Lu S.-M., Yu L., Tian J.-J., Li J.-F., Wang H.-B., Xu W.
Oncol. Rep. 26:1189-1195(2011).
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Clin. Cancer Res. 17:7248-7264(2011).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
DNA-bound platinum is the major determinant of cisplatin sensitivity in head and neck squamous carcinoma cells.
Honeywell R.J., Peters G.J., Braakhuis B.J.M., Brakenhoff R.H.
PLoS ONE 8:E61555-E61555(2013).
A comprehensive transcriptional portrait of human cancer cell lines.
Settleman J., Seshagiri S., Zhang Z.-M.
Nat. Biotechnol. 33:306-312(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
Upregulated interleukin-6 expression contributes to erlotinib resistance in head and neck squamous cell carcinoma.
Simons A.L.
Mol. Oncol. 9:1371-1383(2015).
Defects in the Fanconi anemia pathway and chromatid cohesion in head and neck cancer.
Ylstra B., Joenje H., Feller S.M., Brakenhoff R.H.
Cancer Res. 75:3543-3553(2015).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
JunB promotes cell invasion, migration and distant metastasis of head and neck squamous cell carcinoma.
Ito Y., Myers J.N., Oridate N.
J. Exp. Clin. Cancer Res. 35:6.1-6.12(2016).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
Characterization of human cancer cell lines by reverse-phase protein arrays.
Liang H.
Cancer Cell 31:225-239(2017).
Spheroid-based 3D cell cultures enable personalized therapy testing and drug discovery in head and neck cancer.
Schwenk-Zieger S., Stauber R.H., Baumeister P., Becker S.
Anticancer Res. 37:2201-2210(2017).
Characterization of FaDu-R, a radioresistant head and neck cancer cell line, and cancer stem cells.
Cho K.-J., Park E.-J., Kim M.-S., Joo Y.-H.
Auris Nasus Larynx 45:566-573(2018).
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Oncotarget 8:86369-86383(2017).
Evofosfamide for the treatment of human papillomavirus-negative head and neck squamous cell carcinoma.
Hart C.P., Print C.G., Wilson W.R., Curran M.A., Hunter F.W.
JCI Insight 3:e122204.1-e122204.19(2018).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Nature 568:511-516(2019).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
Characterization of a head and neck cancer-derived cell line panel confirms the distinct TP53-proficient copy number-silent subclass.
Leemans C.R., Wolthuis R.M.F., Brakenhoff R.H.
Oral Oncol. 98:53-61(2019).
Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
Sellers W.R., Gygi S.P.
Cell 180:387-402.e16(2020).
Genotyping and characterization of HPV status, hypoxia, and radiosensitivity in 22 head and neck cancer cell lines.
Gottgens E.-L., Ansems M., Leenders W.P.J., Bussink J., Span P.N.
Cancers (Basel) 13:1069.1-1069.12(2021).