FTC-133Homo sapiens (Human)Cancer cell line
Also known as: FTC133, FTC-113, CFT-133 (In the French and Spanish abstracts where the abbreviation 'FTC' was translated to 'CFT' and thus also the cell line names.)
Quick Overview
Human thyroid cancer cell line with known mutations and applications in cancer research.
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_1219 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Thyroid gland[UBERON:UBERON_0002046] |
Donor Information
| Age | 42 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Differentiated thyroid carcinoma |
|---|---|
| Lineage | Thyroid |
| Subtype | Follicular Thyroid Cancer |
| OncoTree Code | THFO |
DepMap Information
| Source Type | ECACC |
|---|---|
| Source ID | ACH-000903_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Arg273His (c.818G>A) | Homozygous | - | Unknown, PubMed=16264262 |
| MutationSimple | TERT | c.1-124C>T (c.228C>T) (C228T) | Unspecified | In promoter | from parent cell line Hep-G2 |
| MutationSimple | PTEN | p.Arg130Ter (c.388C>T) | Homozygous | - | Unknown, Unknown |
| MutationSimple | NF1 | p.Cys167Ter (c.501T>A) | Homozygous | - | PubMed=30737244 |
| MutationSimple | MSH6 | p.Lys1045fs (c.3135delG) | Homozygous | - | PubMed=30737244 |
| MutationSimple | FLCN | p.His429Thrfs*39 (c.1285delC) | Homozygous | - | PubMed=30737244 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
The CellBox-2 mission to the International Space Station: thyroid cancer cells in space.
Grimm D.
Int. J. Mol. Sci. 22:8777.1-8777.21(2021).
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.
van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.
Nat. Commun. 10:3574.1-3574.11(2019).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
Fagin J.A., Schweppe R.E.
Clin. Cancer Res. 25:3141-3151(2019).
ROS-induced near-homozygous genomes in thyroid cancer.";
van Wezel T., Morreau H.
Endocr. Relat. Cancer 25:83-97(2018).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
Identification of proteins involved in inhibition of spheroid formation under microgravity.
Schwarzwalder A., Aleshcheva G., Corydon T.J., Infanger M., Grimm D.
Proteomics 15:2945-2952(2015).
A resource for cell line authentication, annotation and quality control.
Neve R.M.
Nature 520:307-311(2015).
Aberrant lipid metabolism in anaplastic thyroid carcinoma reveals stearoyl CoA desaturase 1 as a novel therapeutic target.
Tun H.W., Smallridge R.C., Copland J.A. 3rd
J. Clin. Endocrinol. Metab. 100:E697-E709(2015).
Differential gene expression profile and altered cytokine secretion of thyroid cancer cells in space.
Hemmersbach R., Wasser K., Grosse J., Infanger M., Grimm D.
FASEB J. 28:813-835(2014).
Spheroid formation of human thyroid cancer cells in an automated culturing system during the Shenzhou-8 Space mission.
Segerer J., Birlem M., Horn A., Bauer J., Infanger M., Grimm D.
Biomaterials 34:7694-7705(2013).
Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.
Ibrahimpasic T., Ghossein R.A., Fagin J.A.
J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013).
Thyroid cancer cell lines: an overview.";
van Staveren W.C.G., Maenhaut C.
Front. Endocrinol. 3:133.1-133.9(2012).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification.
Haugen B.R.
J. Clin. Endocrinol. Metab. 93:4331-4341(2008).
Human thyroid tumor cell lines derived from different tumor types present a common dedifferentiated phenotype.
Franc B., Thomas G., Libert F., Dumont J.-E., Detours V., Maenhaut C.
Cancer Res. 67:8113-8120(2007).
p73 tumor-suppressor activity is impaired in human thyroid cancer.";
Vigneri P.
Cancer Res. 63:5829-5837(2003).
Actin architecture of cultured human thyroid cancer cells: predictor of differentiation?
Demeure M.J., Hughes-Fulford M.E., Goretzki P.E., Duh Q.-Y., Clark O.H.
Surgery 108:986-993(1990).
Thyroid cell lines in research on goitrogenesis.";
Gerber H., Peter H.-J., Asmis L., Studer H.
Thyroidology 3:115-118(1991).
Anecdotal Information
- Have been flown in space on Shenzhou-8 and on the ISS to study growth in microgravity (PubMed=23866977; PubMed=24196587; PubMed=25930030)