G-361Homo sapiens (Human)Cancer cell line

Also known as: G361mel, G361-mel, G361

🤖 AI SummaryBased on 11 publications

Quick Overview

Human melanoma cell line with BRAF mutations and overexpressed wild-type B-Raf.

Detailed Summary

The G-361 cell line is a human melanoma cell line characterized by the presence of BRAF mutations and overexpression of wild-type B-Raf. Research has shown that these cells exhibit constitutive activation of the MAPK pathway due to overexpression of wild-type B-Raf, which is not solely dependent on gene amplification. The cell line has been used in studies to investigate the role of BRAF mutations and wild-type B-Raf in melanoma progression and drug sensitivity. Additionally, G-361 has been part of large-scale genomic and transcriptomic analyses to identify gene fusions and mutations associated with cancer development.

Research Applications

Investigation of BRAF mutations and wild-type B-Raf overexpression in melanomaAnalysis of MAPK pathway activation in cancer cellsIdentification of gene fusions and mutations in cancer developmentDrug sensitivity profiling for targeted therapies

Key Characteristics

BRAF mutationsOverexpression of wild-type B-RafConstitutive MAPK pathway activationPart of large-scale genomic and transcriptomic studies

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1220
Species	Homo sapiens (Human)
Tissue Source	Skin[UBERON:UBERON_0002097]

Donor Information

Age	31
Age Category	Adult
Sex	Male
Race	caucasian

Disease Information

Disease	Melanoma
Lineage	Skin
Subtype	Melanoma
OncoTree Code	MEL

DepMap Information

Source Type	ATCC
Source ID	ACH-000572_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TERT	c.242_243CC>TT (-138/-139CC>TT)	Unspecified	In promoter	PubMed=23348503
MutationSimple	BRAF	p.Val600Glu (c.1799T>A)	Unspecified	-	PubMed=26214590

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D10S1248

D12S391

17,18

D13S317

D16S539

D18S51

15,16

D19S433

12,16

D1S1656

17.3

D21S11

29,30

D22S1045

D2S1338

16,17

D2S441

10,11

D3S1358

11,16

D5S818

D7S820

8,11

D8S1179

12,13

FGA

19,21

Penta D

9,10,11

Penta E

10,14

TH01

7,9

TPOX

8,10

vWA

15,17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Involvement of overexpressed wild-type BRAF in the growth of malignant melanoma cell lines.

Yasui K., Misawa-Furihata A., Kawakami Y., Inazawa J.

Oncogene 23:8796-8804(2004).

DOI PubMed

Mutations of the BRAF gene in human cancer.";

Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.

Nature 417:949-954(2002).

DOI PubMed

Degradation of alpha-melanocyte stimulating hormone (alpha-MSH) by CALLA/endopeptidase 24.11 expressed by human melanoma cells in culture.

Ghanem G., Lejeune F.

Int. J. Cancer 46:1124-1130(1990).

DOI PubMed

Isolation of four unusual pediatric solid tumor cell lines.";

Peebles P.T., Triche T.J., Papageorge A.G.

Pediatr. Res. 12:485-485(1978).

DOI

Web Resources

tcpaportal.org atcc.org