G-402Homo sapiens (Human)Cancer cell line

Also known as: G402

🤖 AI SummaryBased on 6 publications

Quick Overview

Human cancer cell line with potential for drug sensitivity studies.

Detailed Summary

G-402 is a human cancer cell line derived from an unspecified tissue and disease type. It is part of a large panel of cancer cell lines used for genomic and transcriptomic studies. Research has identified various genetic and molecular characteristics, including potential oncogenic fusions and mutations, which may be relevant for understanding cancer biology and developing targeted therapies. The cell line is utilized in studies related to drug sensitivity and resistance, contributing to the identification of predictive biomarkers for cancer treatment.

Research Applications

Genomic and transcriptomic studiesDrug sensitivity and resistance studiesIdentification of oncogenic fusions and mutations

Key Characteristics

Potential for drug sensitivity studiesOncogenic fusion eventsGenetic and molecular characterization

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1221
Species	Homo sapiens (Human)
Tissue Source	Kidney[UBERON:UBERON_0002113]

Donor Information

Age Category	Pediatric
Sex	Female
Race	caucasian

Disease Information

Disease	Kidney neoplasm
Lineage	Kidney
Subtype	Renal Cell Carcinoma
OncoTree Code	RCC

DepMap Information

Source Type	ATCC
Source ID	ACH-000375_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

10,13

D13S317

9,12

D16S539

11,13

D18S51

12,16

D19S433

13,17

D21S11

30,31

D2S1338

18,21

D3S1358

15,17

D5S818

11,12

D7S820

9,10

D8S1179

14,15

FGA

22,27

Penta D

9,13

Penta E

8,15

TH01

7,9

TPOX

vWA

13,17

Gene Expression Profile

Gene expression levels and statistical distribution

Loading cohorts...

Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC