GA-10Homo sapiens (Human)Cancer cell line

Also known as: GA10

🤖 AI SummaryBased on 6 publications

Quick Overview

GA-10 is a Burkitt's lymphoma cell line with mutant p53 genes, used for cancer research.

Detailed Summary

GA-10 is a Burkitt's lymphoma cell line derived from a patient with chemorefractory disease. It exhibits mutant p53 genes, which may contribute to its resistant phenotype. The cell line is characterized by its rapid proliferation and sensitivity to flavopiridol, a CDK inhibitor. GA-10 shows heterogeneous CD77 expression, affecting its response to Shiga toxin. It is used in studies of apoptosis, drug resistance, and cell cycle regulation. The cell line is also part of research on oncogenic fusions and genetic alterations in cancer.

Research Applications

Apoptosis studiesDrug resistance mechanismsCell cycle regulationOncogenic fusion analysisGenetic alterations in cancer

Key Characteristics

Mutant p53 genesHeterogeneous CD77 expressionSensitivity to flavopiridolRapid proliferation

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1222
Species	Homo sapiens (Human)
Tissue Source	Peripheral blood[UBERON:UBERON_0000178]

Donor Information

Age	41
Age Category	Adult
Sex	Male
Race	caucasian

Disease Information

Disease	Burkitt lymphoma
Lineage	Lymphoid
Subtype	Burkitt Lymphoma
OncoTree Code	BL

DepMap Information

Source Type	ATCC
Source ID	ACH-000162_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Ile232Asn (c.695T>A)	Heterozygous	-	PubMed=29970484
MutationSimple	TP53	p.Pro152Leu (c.455C>T)	Unspecified	-	PubMed=21602893

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

D13S317

D16S539

11,12

D18S51

14,18

D19S433

12,14

D21S11

28,30

D2S1338

D3S1358

D5S818

D7S820

8,10

D8S1179

11,13

FGA

20,23

Penta D

9,13

Penta E

5,12

TH01

9,9.3

TPOX

8,11

vWA

16,20

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.

O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.

J. Virol. 89:713-729(2015).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Flavopiridol induces apoptosis and caspase-3 activation of a newly characterized Burkitt's lymphoma cell line containing mutant p53 genes.

Abboud C.N.

Blood Cells Mol. Dis. 27:610-624(2001).

DOI PubMed