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GaMGHomo sapiens (Human)Cancer cell line

Also known as: GA-MG, GAMG, GaMg

🤖 AI SummaryBased on 6 publications

Quick Overview

Human glioblastoma cell line for cancer research.

Detailed Summary

GaMG is a human glioblastoma cell line derived from a brain tumor. It is used in research to study the molecular mechanisms of glioblastoma and to develop targeted therapies. The cell line is part of the Cancer Cell Line Encyclopedia (CCLE) and has been characterized for its genetic and molecular profiles. GaMG is utilized in studies involving drug sensitivity, genomic alterations, and cancer biology. It provides a valuable model for understanding the complexities of glioblastoma and testing potential therapeutic strategies.

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1226
Species	Homo sapiens (Human)
Tissue Source	Brain[UBERON:UBERON_0000955]

Donor Information

Age	42
Age Category	Adult
Sex	Female

Disease Information

Disease	Glioblastoma
Lineage	CNS/Brain
Subtype	Glioblastoma
OncoTree Code	GB

DepMap Information

Source Type	DSMZ
Source ID	ACH-000098_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Leu265Pro (c.794T>C)	Unspecified	-	PubMed=16541312
MutationSimple	TERT	c.1-124C>T (c.228C>T) (C228T)	Unspecified	In promoter	from parent cell line Hep-G2

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

10

D13S317

11

D16S539

11,13

D18S51

15

D19S433

13

D21S11

29,32.2

D2S1338

17

D3S1358

11,15

D5S818

10,11

D7S820

9,10

D8S1179

13,14

FGA

20,25

Penta D

10,13

Penta E

7,11

TH01

6,9.3

TPOX

8

vWA

14,19

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

Detection of viral proteins in human cells lines by xeno-proteomics: elimination of the last valid excuse for not testing every cellular proteome dataset for viral proteins.

Chernobrovkin A.L., Zubarev R.A.

PLoS ONE 9:E91433-E91433(2014).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Comparative proteomic analysis of eleven common cell lines reveals ubiquitous but varying expression of most proteins.

Geiger T., Wehner A., Schaab C., Cox J., Mann M.

Mol. Cell. Proteomics 11:M111.014050-M111.014050(2012).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Differential effects of 12-O-tetradecanoyl-13-phorbol acetate (TPA) on growth, migration and invasion of a human glioma cell line.

Tysnes O.-B., Laerum O.D.

Anticancer Res. 13:1325-1330(1993).

Characteristics of human and rat glioma cells grown in a defined medium.

Akslen L.A., Andersen K.-J., Bjerkvig R.

Anticancer Res. 8:797-803(1988).

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