GB-1Homo sapiens (Human)Cancer cell line

Also known as: GB1

🤖 AI SummaryBased on 8 publications

Quick Overview

Human glioblastoma cell line for cancer research.

Detailed Summary

GB-1 is a human glioblastoma cell line derived from a glioma tumor. It is used in research to study cancer biology, drug sensitivity, and genetic alterations. The cell line has been part of studies involving genomic profiling, drug response, and cancer cell line encyclopedias. It is utilized in investigations related to cancer genetics, molecular mechanisms, and therapeutic strategies. GB-1 is part of the Cancer Cell Line Encyclopedia (CCLE) and has been used in studies examining copy number variations, gene expression, and drug sensitivity profiles. It is also involved in research on the effects of chemotherapy agents and targeted therapies on cancer cells.

Research Applications

Cancer researchGenomic profilingDrug sensitivity studiesMolecular mechanisms of cancerTherapeutic strategies

Key Characteristics

Glioblastoma cell linePart of Cancer Cell Line Encyclopedia (CCLE)Used in studies on copy number variations and gene expression

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1227
Species	Homo sapiens (Human)
Tissue Source	Brain[UBERON:UBERON_0000955]

Donor Information

Age	35
Age Category	Adult
Sex	Male

Disease Information

Disease	Glioblastoma
Lineage	CNS/Brain
Subtype	Glioblastoma
OncoTree Code	GB

DepMap Information

Source Type	HSRRB
Source ID	ACH-000738_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Asn239_Ser240insAsn (c.716_717insTAA)	Homozygous	-	Unknown, Unknown
MutationSimple	TERT	c.1-124C>T (c.228C>T) (C228T)	Unspecified	In promoter	from parent cell line Hep-G2

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

10,12

D13S317

D16S539

D18S51

13,14

D19S433

13,15.2

D21S11

D2S1338

20,22

D3S1358

15,16

D5S818

10,13

D7S820

11,12

D8S1179

FGA

23.2

Penta D

9,13

Penta E

15,21

TH01

6,7

TPOX

8,11

vWA

16,17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Overexpressed Skp2 within 5p amplification detected by array-based comparative genomic hybridization is associated with poor prognosis of glioblastomas.

Aoyagi M., Ohno K., Imoto I., Inazawa J.

Cancer Sci. 96:676-683(2005).

DOI PubMed PMC

Potentiation of vincristine effect in human and murine gliomas by calcium channel blockers or calmodulin inhibitors.

Kaba K., Tani E., Morimura T., Matsumoto T.

J. Neurosurg. 63:905-911(1985).

DOI PubMed

Effect of CDDP on cultured glioma cell lines: analysis of cell kinetics by flow cytometry.

Morimura T., Kaji K.

Gan To Kagaku Ryoho 13:3150-3154(1986).

PubMed

Prolongation of G1 phase in cultured glioma cells by cis-dichlorodiammineplatinum (II) (CDDP): analysis using bromodeoxyuridine (BrdU)-Hoechst technique.

Morimura T.

J. Neurooncol. 7:71-79(1989).

DOI PubMed