GCTHomo sapiens (Human)Cancer cell line
Also known as: University of Rochester-Human Cell Line-1, UR-HCL-1, Giant Cell Tumor
Quick Overview
Human cell line from malignant fibrous histiocytoma
Detailed Summary
Basic Information
| Database ID | CVCL_1229 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Lung[UBERON:UBERON_0002048] |
Donor Information
| Age | 29 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Undifferentiated pleomorphic sarcoma |
|---|---|
| Lineage | Soft Tissue |
| Subtype | Undifferentiated Pleomorphic Sarcoma/Malignant Fibrous Histiocytoma/High-Grade Spindle Cell Sarcoma |
| OncoTree Code | MFH |
DepMap Information
| Source Type | ATCC |
|---|---|
| Source ID | ACH-000835_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Gln317Ter (c.948_949delinsTT) (c.948_949CC>TT) | Heterozygous | - | from parent cell line GCT |
| MutationSimple | TP53 | p.Arg248Trp (c.742C>T) | Homozygous | Somatic mutation acquired during proliferation | from parent cell line VCaP |
| MutationSimple | CDKN2A | p.Leu32Arg (c.95_96TG>GT) | Homozygous | - | from parent cell line GCT |
| MutationSimple | BRAF | p.Val600Glu (c.1799T>A) | Unspecified | - | PubMed=26214590 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
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Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
Mutations of the BRAF gene in human cancer.";
Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.
Nature 417:949-954(2002).
Phenotypic characterization of the human fibrous histiocytoma giant cell tumor (GCT) cell line and its cytokine repertoire.
Gasson J.C., Abboud C.N.
Exp. Hematol. 21:1342-1352(1993).
Fibrous histiocytoma cell line: chromosome studies of mouse and man.";
Hecht F., Berger C.S., Kaiser-McCaw Hecht B., Speiser B.L.
Cancer Genet. Cytogenet. 8:359-362(1983).