GDM-1Homo sapiens (Human)Cancer cell line

Also known as: GDM1, GMD-1

🤖 AI SummaryBased on 8 publications

Quick Overview

GDM-1 is a human myelomonoblastic cell line derived from a patient with a Philadelphia chromosome-negative myeloproliferative d...

Detailed Summary

GDM-1 is a permanent cell line established from the peripheral blood of a patient with a Philadelphia chromosome-negative myeloproliferative disorder that transformed into acute myelomonoblastic leukemia. The cell line exhibits characteristics of myelomonocytic differentiation, including the presence of non-specific esterase, myeloperoxidase, and lysozyme, as well as Fc and complement (C3) receptors. GDM-1 cells lack B- and T-cell surface markers and do not express surface immunoglobulins or EBV-associated nuclear antigens. The cell line shows a distinct karyotype with chromosomal abnormalities including trisomy 8, deletion of chromosome 6, and deletion of chromosome 12. GDM-1 has been used in studies related to myeloid differentiation, phagocytic activity, and cytogenetic analysis.

Key Characteristics

Expresses non-specific esterase, myeloperoxidase, and lysozymeLacks B- and T-cell markersShows trisomy 8 and deletions of chromosomes 6 and 12Capable of phagocytosis

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1230
Species	Homo sapiens (Human)
Tissue Source	Peripheral blood[UBERON:UBERON_0000178]

Donor Information

Age	66
Age Category	Adult
Sex	Female
Race	caucasian

Disease Information

Disease	Acute myeloid leukemia
Lineage	Myeloid
Subtype	Acute Myeloid Leukemia
OncoTree Code	AML

DepMap Information

Source Type	ATCC
Source ID	ACH-000081_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

11,12

D16S539

D18S51

12,13

D19S433

13,15

D21S11

D2S1338

17,20

D3S1358

14,15

D5S818

D7S820

11,12

D8S1179

14,16

FGA

22,23

Penta D

8,11

Penta E

15,20

TH01

TPOX

8,11

vWA

16,17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.

van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.

Nat. Commun. 10:3574.1-3574.11(2019).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

DOI PubMed PMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.

Haferlach T., Shirahige K., Miyano S., Ogawa S.

Nat. Genet. 45:1232-1237(2013).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.

Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.

Leukemia 20:471-476(2006).

DOI PubMed

Establishment and characterization of a new permanent cell line (GDM-1) from a patient with myelomonoblastic leukemia.

Ben-Bassat H., Korkesh A., Voss R., Leizerowitz R., Polliack A.

Leuk. Res. 6:743-752(1982).

DOI PubMed

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI