GMS-10Homo sapiens (Human)Cancer cell line
Also known as: GMS10
🤖 AI SummaryBased on 5 publications
Quick Overview
Human cancer cell line with unknown tissue and disease origin, used in cancer research.
Detailed Summary
GMS-10 is a human cancer cell line with unknown tissue and disease origin. It is part of the Cancer Cell Line Encyclopedia (CCLE) and has been used in studies related to drug sensitivity and genomic profiling. The cell line's genetic and molecular characteristics are being explored to understand cancer biology and develop targeted therapies. Research on GMS-10 focuses on identifying genetic mutations and their impact on drug response, contributing to the broader understanding of cancer mechanisms and treatment strategies.
Research Applications
Cancer researchDrug sensitivity profilingGenomic profiling
Key Characteristics
Part of the Cancer Cell Line Encyclopedia (CCLE)Used in studies of drug response and genetic mutations
Generated on 6/16/2025
Basic Information
| Database ID | CVCL_1233 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Brain[UBERON:UBERON_0000955] |
Donor Information
| Age | 49 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Glioblastoma |
|---|---|
| Lineage | CNS/Brain |
| Subtype | Glioblastoma |
| OncoTree Code | GB |
DepMap Information
| Source Type | DSMZ |
|---|---|
| Source ID | ACH-000102_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Tyr236Cys (c.707A>G) | Heterozygous | - | Unknown, Unknown |
| MutationSimple | RB1 | p.Arg320Ter (c.958C>T) | Heterozygous | - | PubMed=25326674 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X,Y
CSF1PO
12,13
D13S317
11
D16S539
9,13
D18S51
13,17,18
D19S433
14
D21S11
28
D2S1338
19,24
D3S1358
14,18
D5S818
11,14
D7S820
9,11
D8S1179
14
FGA
17
Penta D
13
Penta E
10,16
TH01
6
TPOX
11
vWA
16
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Golub T.R., Root D.E., Hahn W.C.
Sci. Data 1:140035-140035(2014).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).