GOTOHomo sapiens (Human)Cancer cell line
Quick Overview
Human neuroblastoma cell line with potential for cancer research.
Detailed Summary
Basic Information
| Database ID | CVCL_1234 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Adrenal gland[UBERON:UBERON_0002369] |
Donor Information
| Age | 1 |
|---|---|
| Age Category | Pediatric |
| Sex | Male |
| Race | unknown |
Disease Information
| Disease | Neuroblastoma |
|---|---|
| Lineage | Peripheral Nervous System |
| Subtype | Neuroblastoma |
| OncoTree Code | NBL |
DepMap Information
| Source Type | JCRB |
|---|---|
| Source ID | ACH-001716_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | NRAS | p.Gln61Leu (c.182A>T) | Unspecified | - | PubMed=26214590 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Loading gene expression data...
Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
Oncogenic mutations of ALK kinase in neuroblastoma.";
Hayashi Y., Mano H., Ogawa S.
Nature 455:971-974(2008).
Identification of side population cells (stem-like cell population) in pediatric solid tumor cell lines.
Hayashi Y.
J. Pediatr. Surg. 42:2040-2045(2007).
PPM1D is a potential target for 17q gain in neuroblastoma.";
Sugimoto T., Inazawa J.
Cancer Res. 63:1876-1883(2003).
Screening the p53 status of human cell lines using a yeast functional assay.
Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Mol. Carcinog. 19:243-253(1997).
Establishment and characterization of a human neuroblastoma cell line in tissue culture.
Sekiguchi M., Oota T., Sakakibara K., Inui N., Fujii G.
Jpn. J. Exp. Med. 49:67-83(1979).
Differentiation of human neuroblastoma cells in vitro -- morphological changes induced by dibutyrl cyclic AMP.
Ishikawa S.
Acta Pathol. Jpn. 27:697-711(1977).
Tumor cell lines of the peripheral nervous system.";
Israel M.A., Thiele C.J.
(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.43-78; Academic Press; New York; USA (1994).
Homogeneously staining regions and double minute chromosomes, prevalent cytogenetic abnormalities of human neuroblastoma cells.
Biedler J.L., Meyers M.B., Spengler B.A.
(In book chapter) Advances in cellular neurobiology, Vol. 4; Fedoroff S., Hertz L. (eds.); pp.267-307; Academic Press; New York; USA (1983).