HCC1419Homo sapiens (Human)Cancer cell line

Also known as: Hamon Cancer Center 1419, HCC-1419

🤖 AI SummaryBased on 1 publications

Quick Overview

Human breast cancer cell line with ERBB2 amplification and luminal subtype.

Detailed Summary

HCC1419 is a human breast cancer cell line derived from a luminal subtype tumor with ERBB2 amplification. It is commonly used in research to study the molecular mechanisms of breast cancer, particularly focusing on the role of ERBB2 in tumor progression and therapeutic resistance. The cell line exhibits characteristics of luminal breast cancer, including hormone receptor expression, and is valuable for investigating targeted therapies against ERBB2 and other key signaling pathways. Its genetic profile makes it a relevant model for studying the efficacy of HER2-targeted treatments and understanding the biological behavior of ERBB2-positive breast cancers.

Research Applications

Study of ERBB2 amplification in breast cancerInvestigation of luminal subtype molecular mechanismsDevelopment of HER2-targeted therapiesAnalysis of therapeutic resistance mechanisms

Key Characteristics

ERBB2 amplificationLuminal subtypeHormone receptor expressionHER2-targeted therapy research
Generated on 6/16/2025

Basic Information

Database IDCVCL_1251
SpeciesHomo sapiens (Human)
Tissue SourceBreast[UBERON:UBERON_0000310]

Donor Information

Age42
Age CategoryAdult
SexFemale
Subtype FeaturesHER2+

Disease Information

DiseaseBreast ductal carcinoma
LineageBreast
SubtypeBreast Invasive Ductal Carcinoma
OncoTree CodeIDC

DepMap Information

Source TypeATCC
Source IDACH-000277_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleTP53p.Tyr220Cys (c.659A>G)Unspecified-PubMed=21173094
MutationSimpleTP53p.Ala74fs*47 (c.220_226delGCCCCTG)Heterozygous-from parent cell line HCC1419

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X
CSF1PO
10,12
D13S317
9,12
D16S539
11,12
D18S51
14
D19S433
12,15
D21S11
27,30
D2S1338
17,23
D3S1358
14,17
D5S818
10,12
D7S820
11
D8S1179
13,15
FGA
20,24
Penta D
11,13
Penta E
15,21
TH01
6,9.3
TPOX
8
vWA
16,17
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.

Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.

OncoImmunology 3:e954893.1-e954893.12(2014).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

Modeling precision treatment of breast cancer.";

Collisson E.A., van 't Veer L.J., Spellman P.T., Gray J.W.

Genome Biol. 14:R110.1-R110.14(2013).

miRNA expression profiling of 51 human breast cancer cell lines reveals subtype and driver mutation-specific miRNAs.

Martens J.W.M.

Breast Cancer Res. 15:R33.1-R33.17(2013).

Essential gene profiles in breast, pancreatic, and ovarian cancer cells.

Rottapel R., Neel B.G., Moffat J.

Cancer Discov. 2:172-189(2012).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery.

Pollack J.R.

PLoS ONE 4:E6146-E6146(2009).

Searching for microsatellite mutations in coding regions in lung, breast, ovarian and colorectal cancers.

Minna J.D.

Oncogene 20:1005-1009(2001).

Comparison of features of human breast cancer cell lines and their corresponding tumors.

Gazdar A.F.

Clin. Cancer Res. 4:2931-2938(1998).

Characterization of paired tumor and non-tumor cell lines established from patients with breast cancer.

Tomlinson G.E., Tonk V., Ashfaq R., Leitch A.M., Minna J.D., Shay J.W.

Int. J. Cancer 78:766-774(1998).