HCC2935Homo sapiens (Human)Cancer cell line

Also known as: Hamon Cancer Center 2935, HCC-2935

🤖 AI SummaryBased on 7 publications

Quick Overview

Human cancer cell line with potential applications in lung cancer research.

Detailed Summary

HCC2935 is a human cancer cell line derived from lung tissue, though the specific tissue type is not specified. It is associated with small cell lung cancer (SCLC) based on its inclusion in studies comparing SCLC and non-small cell lung cancer (NSCLC) cell lines. Research on HCC2935 has focused on identifying dysregulated pathways and potential therapeutic targets, including the role of PARP1 and the immunoproteasome in cancer progression. The cell line has been used to study the molecular differences between SCLC and NSCLC, particularly in terms of protein expression profiles and immune evasion mechanisms. Additionally, HCC2935 has been implicated in studies related to epithelial-mesenchymal transition (EMT) and its association with poor prognosis in NSCLC. The cell line's utility in understanding cancer biology and developing targeted therapies is highlighted by its inclusion in comprehensive datasets such as the Cancer Cell Line Encyclopedia (CCLE) and the Catalogue of Somatic Mutations in Cancer (COSMIC).

Research Applications

Small cell lung cancer (SCLC) researchComparative analysis of SCLC and NSCLCIdentification of therapeutic targets (e.g., PARP1, immunoproteasome)Studies on epithelial-mesenchymal transition (EMT)Investigation of immune evasion mechanismsGenomic and transcriptomic profiling

Key Characteristics

Dysregulated protein expression profilesPotential role in PARP1 and immunoproteasome researchInvolvement in EMT and cancer progression studiesUsed in comprehensive cancer cell line datasets (CCLE, COSMIC)

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1265
Species	Homo sapiens (Human)

Donor Information

Age	39
Age Category	Adult
Sex	Male
Race	caucasian

Disease Information

Disease	Lung adenocarcinoma
Lineage	Lung
Subtype	Lung Adenocarcinoma
OncoTree Code	LUAD

DepMap Information

Source Type	ATCC
Source ID	ACH-000150_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Tyr220Cys (c.659A>G)	Unspecified	-	PubMed=21173094
MutationSimple	APC	p.Gln1367Ter (c.4099C>T)	Homozygous	-	from parent cell line Caco-2

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

D13S317

D16S539

D18S51

D19S433

13,15

D21S11

D2S1338

17,19

D3S1358

D5S818

D7S820

12,13

D8S1179

FGA

Penta D

Penta E

7,12

TH01

7,9

TPOX

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.

Aldige C.R., Wistuba I.I., Minna J.D.

J. Cell. Biochem. 121:3986-3999(2020).

DOI PubMed PMC

Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.

van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.

Nat. Commun. 10:3574.1-3574.11(2019).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Chemistry-first approach for nomination of personalized treatment in lung cancer.

Posner B.A., Minna J.D., Kim H.S., White M.A.

Cell 173:864-878.e29(2018).

DOI PubMed PMC

Immunoproteasome deficiency is a feature of non-small cell lung cancer with a mesenchymal phenotype and is associated with a poor outcome.

Hanash S.M., Ostrin E.J.

Proc. Natl. Acad. Sci. U.S.A. 113:E1555-E1564(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

Comparative proteome analysis across non-small cell lung cancer cell lines.

Daub H.

J. Proteomics 130:1-10(2016).

DOI PubMed

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.

Heymach J.V.

Cancer Discov. 2:798-811(2012).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Web Resources

utsouthwestern.edu