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HCC4006Homo sapiens (Human)Cancer cell line

Also known as: Hamon Cancer Center 4006, HCC-4006

🤖 AI SummaryBased on 7 publications

Quick Overview

Human lung cancer cell line with EGFR mutations and resistance mechanisms.

Detailed Summary

HCC4006 is a human lung cancer cell line derived from a patient with non-small cell lung cancer (NSCLC). It is characterized by the presence of EGFR mutations, which are common in lung cancer and often associated with sensitivity to tyrosine kinase inhibitors (TKIs). However, HCC4006 has developed resistance mechanisms, including the T790M mutation in EGFR, which is a well-known secondary mutation that confers resistance to first-generation TKIs. This cell line is also noted for its ability to undergo epithelial-mesenchymal transition (EMT), a process that contributes to cancer progression and resistance. HCC4006 is used in research to study the molecular mechanisms of drug resistance and to develop strategies for overcoming resistance in lung cancer treatment. The cell line has been utilized in studies involving next-generation sequencing to identify genetic alterations associated with resistance, including copy number variations and mutations in genes such as MET and others. These characteristics make HCC4006 a valuable model for understanding the complexities of EGFR-driven lung cancer and the development of targeted therapies.

Research Applications

EGFR mutation analysisDrug resistance mechanismsEpithelial-mesenchymal transition (EMT) studiesNext-generation sequencing for genetic alterationsTargeted therapy development

Key Characteristics

EGFR mutationsT790M resistance mutationEpithelial-mesenchymal transition (EMT)Copy number variationsResistance to first-generation tyrosine kinase inhibitors

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1269
Species	Homo sapiens (Human)
Tissue Source	Pleural effusion[UBERON:UBERON_0000175]

Donor Information

Age Category	Adult
Sex	Male
Race	caucasian

Disease Information

Disease	Lung adenocarcinoma
Lineage	Lung
Subtype	Lung Adenocarcinoma
OncoTree Code	LUAD

DepMap Information

Source Type	ATCC
Source ID	ACH-000066_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Tyr205His (c.613T>C)	Unspecified	-	PubMed=16203773
MutationSimple	EGFR	p.Leu747_Glu749del (c.2239_2247delTAAGAGAA)	Heterozygous	-	from parent cell line HCC4006

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

10

D13S317

11,12

D16S539

11,12

D18S51

19

D19S433

12,13

D21S11

31

D2S1338

17,24

D3S1358

16,18

D5S818

12

D7S820

9,12

D8S1179

10,14

FGA

21,22

Penta D

9,14

Penta E

7,13

TH01

7

TPOX

8,9

vWA

16,17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Potential utility of a 4th-generation EGFR-TKI and exploration of resistance mechanisms -- an in vitro study.

Mitsudomi T., Tsutani Y.

Biomedicines 12:1412.1-1412.13(2024).

Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.

van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.

Nat. Commun. 10:3574.1-3574.11(2019).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Chemistry-first approach for nomination of personalized treatment in lung cancer.

Posner B.A., Minna J.D., Kim H.S., White M.A.

Cell 173:864-878.e29(2018).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

Comparative proteome analysis across non-small cell lung cancer cell lines.

Daub H.

J. Proteomics 130:1-10(2016).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

Next-generation sequencing of paired tyrosine kinase inhibitor-sensitive and -resistant EGFR mutant lung cancer cell lines identifies spectrum of DNA changes associated with drug resistance.

Pirazzoli V., Dahlman K.B., Politi K., Michor F., Zhao Z.-M., Pao W.

Genome Res. 23:1434-1445(2013).

Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.

Heymach J.V.

Cancer Discov. 2:798-811(2012).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Lung cancer cell lines as tools for biomedical discovery and research.

Gazdar A.F., Girard L., Lockwood W.W., Lam W.L., Minna J.D.

J. Natl. Cancer Inst. 102:1310-1321(2010).

High resolution analysis of non-small cell lung cancer cell lines by whole genome tiling path array CGH.

Gazdar A.F., Lam S., MacAulay C., Lam W.L.

Int. J. Cancer 118:1556-1564(2006).

Web Resources

utsouthwestern.edu