HD-MY-ZHomo sapiens (Human)Cancer cell line

Also known as: HDMYZ, HD-MyZ

🤖 AI SummaryBased on 7 publications

Quick Overview

HD-MY-Z is a Hodgkin lymphoma cell line with myelomonocytic features, used for studying tumor biology and therapeutic strategies.

Detailed Summary

HD-MY-Z is a Hodgkin lymphoma cell line established from the pleural effusion of a 29-year-old patient with nodular sclerosing Hodgkin's disease. The cell line exhibits characteristics of myelomonocytic differentiation, including expression of CD13, CD68, and HLA-DR, and lacks lymphoid markers. It constitutively expresses cytokines such as IL-1α, IL-1β, IL-5, IL-6, and IL-8, and shows tumorigenic potential in SCID mice. HD-MY-Z is valuable for studying the pathogenesis of Hodgkin's disease and testing novel therapeutic interventions.

Research Applications

Study of Hodgkin's disease pathogenesisEvaluation of tumor cell biologyTesting of novel therapeutic strategies

Key Characteristics

Myelomonocytic differentiation markers (CD13, CD68, HLA-DR)Constitutive cytokine expression (IL-1α, IL-1β, IL-5, IL-6, IL-8)Tumorigenic potential in SCID mice

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1273
Species	Homo sapiens (Human)
Tissue Source	Pleural effusion[UBERON:UBERON_0000175]

Donor Information

Age	29
Age Category	Adult
Sex	Male

Disease Information

Disease	Acute myeloid leukemia
Lineage	Myeloid
Subtype	Acute Myeloid Leukemia
OncoTree Code	AML

DepMap Information

Source Type	DSMZ
Source ID	ACH-000190_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Tyr234Valfs*2 (c.696_706del11)	Heterozygous	-	Unknown
MutationSimple	NRAS	p.Gly13Asp (c.38G>A)	Unspecified	-	PubMed=32014918

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

D13S317

8,11

D16S539

11,14

D18S51

D19S433

D21S11

28,32.2

D2S1338

19,20

D3S1358

D5S818

D7S820

9,11

D8S1179

12,17

FGA

20,22

Penta D

9,11

Penta E

12,13

TH01

TPOX

10,11

vWA

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

DOI PubMed PMC

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

DOI PubMed PMC

Hodgkin lymphoma cell lines: to separate the wheat from the chaff.";

Drexler H.G., Pommerenke C., Eberth S., Nagel S.

Biol. Chem. 399:511-523(2018).

DOI PubMed

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

The (2;5)(p23;q35) translocation in cell lines derived from malignant lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.

Quentmeier H., Drexler H.G.

Leukemia 10:142-149(1996).

PubMed

Characterization of a novel Hodgkin cell line, HD-MyZ, with myelomonocytic features mimicking Hodgkin's disease in severe combined immunodeficient mice.

Dohner H., Dorken B.

J. Exp. Med. 177:1257-1268(1993).

DOI PubMed PMC

Xenotransplantation of a novel Hodgkin cell line HD-MyZ into SCID mice.";

Bargou R.C., Mapara M.Y., Arnold W., Daniel P.T., Dorken B.

(In book chapter) Immunodeficient animals: models for cancer research. Contributions in Oncology, Vol. 51; Arnold W., Kopf-Maier P., Michael B. (eds.); pp.187-192; Karger; Basel; Switzerland (1996).

DOI

The leukemia-lymphoma cell line factsbook.";

Drexler H.G.

(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).

DOI