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HEC-1Homo sapiens (Human)Cancer cell line

Also known as: HEC-B-296, Human Endometrial Cancer-1, HEC1

🤖 AI SummaryBased on 8 publications

Quick Overview

Human endometrial adenocarcinoma cell line established in 1968 for cancer research.

Detailed Summary

HEC-1 is a human endometrial adenocarcinoma cell line established in 1968, derived from a 71-year-old female patient with endometrial carcinoma. It is one of the first in vitro cell lines for endometrial cancer research, providing a stable system for studying tumor biology and therapeutic responses. HEC-1 cells exhibit epithelial characteristics with anaplastic features, including anisonucleosis and nucleolar pleomorphism. The cell line maintains its original tumor characteristics in culture, showing a diploid chromosomal distribution with a stable marker chromosome. HEC-1 has been used to study hormone responsiveness, drug sensitivity, and tumor formation in xenograft models, contributing to understanding endometrial cancer mechanisms and treatment strategies.

Research Applications

Hormone receptor studiesDrug sensitivity screeningTumor formation in xenograftsChromosomal analysisCell proliferation studies

Key Characteristics

Epithelial morphologyAnaplastic featuresDiploid chromosomal rangeStable marker chromosomeHormone responsiveness

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1274
Species	Homo sapiens (Human)
Tissue Source	Endometrium[UBERON:UBERON_0001295]

Donor Information

Age	71
Age Category	Adult
Sex	Female

Disease Information

Disease	Type II endometrial adenocarcinoma
Lineage	Uterus
Subtype	Endometrial Carcinoma
OncoTree Code	UCEC

DepMap Information

Source Type	JCRB
Source ID	ACH-001517_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg248Gln (c.743G>A)	Unspecified	Somatic mutation acquired during proliferation	PubMed=20575032
MutationSimple	PMS2	p.Arg802Ter (c.2404C>T)	Heterozygous	-	from parent cell line HEC-1
MutationSimple	MSH6	c.4001+1G>T	Heterozygous	Splice donor mutation	from parent cell line HEC-1
MutationSimple	MSH6	p.Phe1088Serfs*2 (c.3261delC)	Homozygous	-	from parent cell line Jurkat
MutationSimple	KRAS	p.Gly12Asp (c.35G>A)	Unspecified	-	PubMed=29786757

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

10,12

D13S317

11

D16S539

11,12

D18S51

16,20,21

D21S11

30,31

D3S1358

15

D5S818

11,13

D7S820

11

D8S1179

13,14

FGA

21,22

Penta D

9,13

Penta E

11

TH01

6,7

TPOX

11

vWA

18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

HEC-1 cells.";

Kuramoto H., Hamano M., Imai M.

Hum. Cell 15:81-95(2002).

Screening the p53 status of human cell lines using a yeast functional assay.

Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.

Mol. Carcinog. 19:243-253(1997).

Effect of cell density and confluency on cholesterol metabolism in cancer cells in monolayer culture.

Gal D., MacDonald P.C., Porter J.C., Smith J.W., Simpson E.R.

Cancer Res. 41:473-477(1981).

Studies of the growth and cytogenetic properties of human endometrial adenocarcinoma in culture and its development into an established line.

Kuramoto H.

Acta Obstet. Gynaecol. Jpn. 19:47-58(1972).

Establishment of a cell line of human endometrial adenocarcinoma in vitro.

Kuramoto H., Tamura S., Notake Y.

Am. J. Obstet. Gynecol. 114:1012-1019(1972).

Establishment and characterization of human endometrial cancer cell lines.

Ohno E., Iida T.

Ann. N. Y. Acad. Sci. 622:402-421(1991).

HEC-1 cells: establishment of an in vitro experimental system in endometrial carcinoma.

Kawaguchi M.

(In book chapter) Cell and molecular biology of endometrial carcinoma; Kuramoto H., Nishida M. (eds.); pp.3-34; Springer; Tokyo; Japan (2003).

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