Back to Cell Types

HGC-27Homo sapiens (Human)Cancer cell line

Also known as: HGC27, HGC 27

🤖 AI SummaryBased on 13 publications

Quick Overview

Human gastric cancer cell line with known mutations and applications in drug sensitivity studies.

Detailed Summary

HGC-27 is a human gastric cancer cell line derived from a patient with gastric cancer. It is widely used in research for studying drug sensitivity and resistance mechanisms. This cell line has been involved in studies related to chemosensitivity profiles, gene expression analysis, and identification of mutations associated with cancer progression. HGC-27 is particularly noted for its role in understanding the molecular mechanisms of gastric cancer and for its utility in preclinical drug testing. The cell line has been characterized in multiple studies, including those focusing on the role of specific genes like PARD3 and its implications in cancer biology.

Research Applications

Chemosensitivity profilingGene expression analysisMutation detectionDrug resistance studiesMolecular mechanism investigation

Key Characteristics

Known mutations in PARD3Used in drug sensitivity assaysCharacterized in multiple genomic studies

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1279
Species	Homo sapiens (Human)
Tissue Source	Lymph node[UBERON:UBERON_0000029]

Donor Information

Age Category	Unknown
Sex	Unknown
Race	asian

Disease Information

Disease	Gastric carcinoma
Lineage	Esophagus/Stomach
Subtype	Stomach Adenocarcinoma
OncoTree Code	STAD

DepMap Information

Source Type	ECACC
Source ID	ACH-000847_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Pro153Alafs*28 (c.455dupC) (c.455_456insC) (p.P152fs) (c.459_460insC)	Heterozygous	-	from parent cell line HGC-27
MutationSimple	PIK3CA	p.Glu542Lys (c.1624G>A)	Unspecified	-	PubMed=31541927
MutationSimple	ATR	p.Gly2316fs*9 (c.6947delG)	Heterozygous	-	from parent cell line HGC-27

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X

CSF1PO

12

D13S317

10,11

D16S539

10,11

D18S51

16

D19S433

14

D21S11

30,33,34

D2S1338

22,24

D3S1358

17

D5S818

12

D7S820

11,12,13

D8S1179

7,11,16

FGA

22

Penta D

9,13

Penta E

18

TH01

9

TPOX

8

vWA

14

Gene Expression Profile

Gene expression levels and statistical distribution

Loading cohorts...

Full DepMap dataset with combined data across cell lines

Loading gene expression data...

Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.

Firestein R., Zhang Z.-M.

Nat. Commun. 5:3830.1-3830.8(2014).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Correlation between DNA alterations and p53 and p16 protein expression in cancer cell lines.

Murai Y., Hayashi S., Takahashi H., Tsuneyama K., Takano Y.

Pathol. Res. Pract. 201:109-115(2005).

Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays.

Yamori T.

Mol. Cancer Ther. 4:399-412(2005).

Short tandem repeat profiling provides an international reference standard for human cell lines.

Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.

Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001).

Alpha-fetoprotein producing gastric cancer lacks transcription factor ATBF1.

Nakabayashi H., Kawaguchi M., Asai K., Kato T., Itoh M.

Oncogene 20:869-873(2001).

Analysis of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced DNA damage in tumor cell strains from Japanese patients and demonstration of MNNG hypersensitivity of Mer xenografts in athymic nude mice.

Kondo S.

Carcinogenesis 6:549-553(1985).

Human cell line (HGC-27) derived from the metastatic lymph node of gastric cancer.

Akagi T., Kimoto T.

Acta Med. Okayama 30:215-219(1976).