HMV-IIHomo sapiens (Human)Cancer cell line

Also known as: Human Melanoma Vagina-II, HMVII, HMV-2

🤖 AI SummaryBased on 6 publications

Quick Overview

HMV-II is a human melanoma cell line used in cancer research.

Detailed Summary

HMV-II is a human melanoma cell line derived from malignant melanoma. It is known for its ability to incorporate 4-S-cysteinylphenol, a tyrosine analog, which is specifically taken up by melanotic melanoma cells. This cell line has been used to study the mechanisms of melanin synthesis and the role of tyrosinase in melanogenesis. HMV-II cells exhibit active melanin synthesis and are often used in studies related to melanoma biology and chemotherapy. The cell line is also noted for its response to tyrosine analogs, which may have implications for targeted cancer therapies.

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1282
Species	Homo sapiens (Human)
Tissue Source	Vagina[UBERON:UBERON_0000996]

Donor Information

Age	65
Age Category	Adult
Sex	Female

Disease Information

Disease	Vaginal melanoma
Lineage	Vulva/Vagina
Subtype	Mucosal Melanoma of the Vulva/Vagina
OncoTree Code	VMM

DepMap Information

Source Type	RIKEN
Source ID	ACH-002040_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Asn268Ile (c.803A>T)	Heterozygous	-	Unknown, Unknown
MutationSimple	NRAS	p.Gln61Lys (c.181C>A)	Unspecified	Acquired during resistance selection process	PubMed=26214590
MutationSimple	BRAF	p.Gly469Val (c.1406G>T)	Heterozygous	-	from parent cell line HCV-29

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D13S317

D16S539

D18S51

D21S11

D3S1358

14,15

D5S818

D7S820

8,14

D8S1179

FGA

Penta D

Penta E

5,21

TH01

6,9

TPOX

vWA

16,17

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Mutations of the BRAF gene in human cancer.";

Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.

Nature 417:949-954(2002).

DOI PubMed

Involvement of overexpressed wild-type BRAF in the growth of malignant melanoma cell lines.

Yasui K., Misawa-Furihata A., Kawakami Y., Inazawa J.

Oncogene 23:8796-8804(2004).

DOI PubMed

Specific incorporation of 4-S-cysteinylphenol into human melanoma cells.

Nakamura T., Seki S., Matsubara O., Ito S., Kasuga T.

J. Invest. Dermatol. 90:725-728(1988).

DOI PubMed

Human malignant melanoma cell line (HMV-II) for isolation of influenza C and parainfluenza viruses.

Numazaki Y.

J. Clin. Microbiol. 28:1147-1150(1990).

DOI PubMed PMC