HSC-2Homo sapiens (Human)Cancer cell line
Also known as: HSC2
Quick Overview
Human oral squamous cell carcinoma cell line for cancer research
Detailed Summary
Research Applications
Key Characteristics
Basic Information
| Database ID | CVCL_1287 |
|---|---|
| Species | Homo sapiens (Human) |
| Tissue Source | Cervical lymph node[UBERON:UBERON_0002429] |
Donor Information
| Age | 69 |
|---|---|
| Age Category | Adult |
| Sex | Male |
Disease Information
| Disease | Squamous cell carcinoma of the oral cavity |
|---|---|
| Lineage | Head and Neck |
| Subtype | Oral Cavity Squamous Cell Carcinoma |
| OncoTree Code | OCSC |
DepMap Information
| Source Type | HSRRB |
|---|---|
| Source ID | ACH-000472_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | c.672+1G>A | Homozygous | Splice donor mutation | Unknown, Unknown, PubMed=1311061 |
| MutationSimple | PIK3CA | p.His1047Arg (c.3140A>G) | Unspecified | - | PubMed=25926053, PubMed=20570890 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
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Publications
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Genome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway.
McDermott U., Garnett M.J., Cheong S.-C.
eLife 9:e57761.1-e57761.34(2020).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Loewer M., Sahin U., Castle J.C.
Genome Med. 7:118.1-118.7(2015).
Alteration of cancer stem cell-like phenotype by histone deacetylase inhibitors in squamous cell carcinoma of the head and neck.
Takahashi K., Masuyama K.
Cancer Sci. 104:1468-1475(2013).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Haber D.A.
Cancer Res. 70:2158-2164(2010).
Signatures of mutation and selection in the cancer genome.";
Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Nature 463:893-898(2010).
The galanin signaling cascade is a candidate pathway regulating oncogenesis in human squamous cell carcinoma.
Sasaki K., Hanazawa T., Okamoto Y., Hata A.
Genes Chromosomes Cancer 48:132-142(2009).
Oncogenic mutations of the PIK3CA gene in head and neck squamous cell carcinomas.
Murugan A.K., Hong N.T., Fukui Y., Munirajan A.K., Tsuchida N.
Int. J. Oncol. 32:101-111(2008).
PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation.
Kozaki K.-i., Amagasa T., Inazawa J.
Oncogene 26:7921-7932(2007).
Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array.
Hamakawa H.
Oncogene 26:5300-5308(2007).
PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma.
Omura K., Inazawa J.
Cancer Sci. 97:1351-1358(2006).
Detection of human papillomavirus-16 and HPV-18 DNA in normal, dysplastic, and malignant oral epithelium.
Sugiyama M., Bhawal U.K., Dohmen T., Ono S., Miyauchi M., Ishikawa T.
Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 95:594-600(2003).
Regulation of cell motility via high and low affinity autocrine motility factor (AMF) receptor in human oral squamous carcinoma cells.
Niinaka Y., Haga A., Negishi A., Yoshimasu H., Raz A., Amagasa T.
Oral Oncol. 38:49-55(2002).
Short tandem repeat profiling provides an international reference standard for human cell lines.
Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001).
Expression of E-cadherin in oral cancer cell lines and its relationship to invasiveness in SCID mice in vivo.
Hoteiya T., Hayashi E., Satomura K., Kamata N., Nagayama M.
J. Oral Pathol. Med. 28:107-111(1999).
Screening the p53 status of human cell lines using a yeast functional assay.
Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Mol. Carcinog. 19:243-253(1997).
HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating lymphocytes of patients with non-small cell lung cancer.
Seki N., Hoshino T., Kikuchi M., Hayashi A., Itoh K.
Cell. Immunol. 175:101-110(1997).
Variant sublines with different metastatic potentials selected in nude mice from human oral squamous cell carcinomas.
Momose F., Araida T., Negishi A., Ichijo H., Shioda S., Sasaki S.
J. Oral Pathol. Med. 18:391-395(1989).
Growth of the malignant and nonmalignant human squamous cells in a protein-free defined medium.
Rikimaru K., Toda H., Tachikawa N., Kamata N., Enomoto S.
In Vitro Cell. Dev. Biol. 26:849-856(1990).
Most human squamous cell carcinomas in the oral cavity contain mutated p53 tumor-suppressor genes.
Sakai E., Tsuchida N.
Oncogene 7:927-933(1992).