HSC-4Homo sapiens (Human)Cancer cell line

Also known as: HSC4

🤖 AI SummaryBased on 14 publications

Quick Overview

Human oral squamous cell carcinoma cell line with E-cadherin expression and potential for cancer research.

Detailed Summary

HSC-4 is a human oral squamous cell carcinoma cell line derived from tongue cancer. It expresses E-cadherin, a cell adhesion molecule, and has been studied for its role in tumor invasiveness and metastasis. Research indicates that HSC-4 exhibits characteristics of cuboidal morphology and forms cobblestone colonies, which are typical of epithelial cells. The cell line has been used in studies examining the relationship between E-cadherin expression and tumor progression, as well as in investigations of genetic alterations such as homozygous deletions and mutations in genes like FAT and PIK3CA. HSC-4 is also part of larger studies on cancer genomics, including the Cancer Cell Line Encyclopedia (CCLE) and other genomic profiling efforts, contributing to the understanding of molecular mechanisms in oral cancer.

Research Applications

Cancer researchGenomic profilingTumor invasiveness and metastasis studiesE-cadherin expression analysisHomozygous deletion and mutation studies

Key Characteristics

Expresses E-cadherinCuboidal morphologyForms cobblestone coloniesUsed in studies of oral cancer genomics

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1289
Species	Homo sapiens (Human)
Tissue Source	Cervical lymph node[UBERON:UBERON_0002429]

Donor Information

Age	64
Age Category	Adult
Sex	Male

Disease Information

Disease	Squamous cell carcinoma of the oral tongue
Lineage	Head and Neck
Subtype	Oral Cavity Squamous Cell Carcinoma
OncoTree Code	OCSC

DepMap Information

Source Type	HSRRB
Source ID	ACH-000546_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg248Gln (c.743G>A)	Unspecified	Somatic mutation acquired during proliferation	PubMed=20575032
MutationSimple	TERT	c.1-124C>T (c.228C>T) (C228T)	Unspecified	In promoter	from parent cell line Hep-G2
MutationSimple	PIK3CA	p.Glu545Lys (c.1633G>A)	Heterozygous	-	from parent cell line MCF-7
MutationSimple	CDKN2A	p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T)	Homozygous	-	from parent cell line HL-60

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

D10S1248

12,13

D12S391

18,19

D13S317

8,13

D16S539

D18S51

15,20

D19S433

13,14

D1S1656

15,16

D21S11

29,30

D22S1045

D2S1338

D2S441

D3S1358

15,16

D5S818

8,11

D7S820

9,10

D8S1179

FGA

Penta D

Penta E

17,19

TH01

6,9

TPOX

vWA

16,19

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Biological and genetic characterization of a newly established human external auditory canal carcinoma cell line, SCEACono2.

Manako T., Kuga R., Hongo T., Kogo R., Onishi H., Nakagawa T.

Sci. Rep. 13:19636-19636(2023).

DOI PubMed PMC

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Genome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway.

McDermott U., Garnett M.J., Cheong S.-C.

eLife 9:e57761.1-e57761.34(2020).

DOI PubMed PMC

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.

Nature 568:511-516(2019).

DOI PubMed

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Oncogenic mutations of the PIK3CA gene in head and neck squamous cell carcinomas.

Murugan A.K., Hong N.T., Fukui Y., Munirajan A.K., Tsuchida N.

Int. J. Oncol. 32:101-111(2008).

DOI PubMed

PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation.

Kozaki K.-i., Amagasa T., Inazawa J.

Oncogene 26:7921-7932(2007).

DOI PubMed

Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array.

Hamakawa H.

Oncogene 26:5300-5308(2007).

DOI PubMed

PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma.

Omura K., Inazawa J.

Cancer Sci. 97:1351-1358(2006).

DOI PubMed PMC

Detection of human papillomavirus-16 and HPV-18 DNA in normal, dysplastic, and malignant oral epithelium.

Sugiyama M., Bhawal U.K., Dohmen T., Ono S., Miyauchi M., Ishikawa T.

Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 95:594-600(2003).

DOI PubMed

Regulation of cell motility via high and low affinity autocrine motility factor (AMF) receptor in human oral squamous carcinoma cells.

Niinaka Y., Haga A., Negishi A., Yoshimasu H., Raz A., Amagasa T.

Oral Oncol. 38:49-55(2002).

DOI PubMed

Short tandem repeat profiling provides an international reference standard for human cell lines.

Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.

Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001).

DOI PubMed PMC

A wild-type sequence p53 peptide presented by HLA-A24 induces cytotoxic T lymphocytes that recognize squamous cell carcinomas of the head and neck.

Song Y.-S., Appella E., Whiteside T.L., DeLeo A.B.

Clin. Cancer Res. 6:979-986(2000).

PubMed

Expression of E-cadherin in oral cancer cell lines and its relationship to invasiveness in SCID mice in vivo.

Hoteiya T., Hayashi E., Satomura K., Kamata N., Nagayama M.

J. Oral Pathol. Med. 28:107-111(1999).

DOI PubMed

Screening the p53 status of human cell lines using a yeast functional assay.

Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.

Mol. Carcinog. 19:243-253(1997).

DOI PubMed

Expression of bone morphogenetic proteins of human neoplastic epithelial cells.

Hatakeyama S., Gao Y.-H., Ohara-Nemoto Y., Kataoka H., Satoh M.

Biochem. Mol. Biol. Int. 42:497-505(1997).

DOI PubMed

HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating lymphocytes of patients with non-small cell lung cancer.

Seki N., Hoshino T., Kikuchi M., Hayashi A., Itoh K.

Cell. Immunol. 175:101-110(1997).

DOI PubMed

Expression of the MAGE gene family in human head-and-neck squamous-cell carcinomas.

Itoh K., Ishikawa T.

Int. J. Cancer 64:304-308(1995).

DOI PubMed

Variant sublines with different metastatic potentials selected in nude mice from human oral squamous cell carcinomas.

Momose F., Araida T., Negishi A., Ichijo H., Shioda S., Sasaki S.

J. Oral Pathol. Med. 18:391-395(1989).

DOI PubMed

Growth of the malignant and nonmalignant human squamous cells in a protein-free defined medium.

Rikimaru K., Toda H., Tachikawa N., Kamata N., Enomoto S.

In Vitro Cell. Dev. Biol. 26:849-856(1990).

DOI PubMed

Most human squamous cell carcinomas in the oral cavity contain mutated p53 tumor-suppressor genes.

Sakai E., Tsuchida N.

Oncogene 7:927-933(1992).

PubMed