HTHomo sapiens (Human)Cancer cell line

🤖 AI SummaryBased on 12 publications

Quick Overview

Human B-cell lymphoma cell line for cancer research

Detailed Summary

The HT cell line is a human B-cell lymphoma cell line derived from a patient with diffuse large B-cell lymphoma (DLBCL). It is widely used in research to study the molecular mechanisms of lymphoma, including the role of BCL-2 in apoptosis and drug resistance. HT has been utilized in studies examining the efficacy of BCL-2 inhibitors like venetoclax and in understanding the genetic and molecular alterations associated with DLBCL. This cell line is also employed in investigations related to the PI3K/AKT/mTOR signaling pathway and its involvement in lymphoma progression. The HT cell line provides a valuable model for studying the biological and therapeutic aspects of DLBCL, contributing to the development of targeted therapies.

Research Applications

Study of BCL-2 in apoptosis and drug resistanceEvaluation of BCL-2 inhibitors like venetoclaxInvestigation of PI3K/AKT/mTOR signaling in lymphoma progressionMolecular mechanisms of DLBCL

Key Characteristics

Human B-cell lymphoma modelUsed in studies of apoptosis and drug resistanceRelevant for PI3K/AKT/mTOR pathway researchUtilized in DLBCL molecular studies
Generated on 6/16/2025

Basic Information

Database IDCVCL_1290
SpeciesHomo sapiens (Human)
Tissue SourceAscites[UBERON:UBERON_0007795]

Donor Information

Age70
Age CategoryAdult
SexMale
Racecaucasian

Disease Information

DiseaseDiffuse large B-cell lymphoma
LineageLymphoid
SubtypeDiffuse Large B-Cell Lymphoma, NOS
OncoTree CodeDLBCLNOS

DepMap Information

Source TypeATCC
Source IDACH-000914_source

Known Sequence Variations

TypeGene/ProteinDescriptionZygosityNoteSource
MutationSimpleTP53p.Arg273His (c.818G>A)Homozygous-Unknown, PubMed=16264262
MutationSimpleTP53p.Val216Met (c.646G>A)Unspecified-Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin
X,Y
CSF1PO
10
D13S317
13,14
D16S539
11,13
D18S51
12,19
D19S433
12,16
D21S11
29,31.2
D2S1338
24,25
D3S1358
15,16
D5S818
11,13
D7S820
7.3,8,10
D8S1179
10,13
FGA
21,22.2
Penta D
13
Penta E
10,20
TH01
6,7
TPOX
11
vWA
17,18
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.

PLoS ONE 14:E0210404-E0210404(2019).

Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.

Yang H.H., Koeffler H.P.

BMC Cancer 18:940.1-940.13(2018).

Smoothened stabilizes and protects TRAF6 from degradation: a novel non-canonical role of smoothened with implications in lymphoma biology.

Lossos I.S., Landgraf R., Vega-Vazquez F.

Cancer Lett. 436:149-158(2018).

Strategic therapeutic targeting to overcome venetoclax resistance in aggressive B-cell lymphomas.

Medeiros L.J., Ford R.J. Jr., Nomie K., Zhang L., Wang M.

Clin. Cancer Res. 24:3967-3980(2018).

Preclinical efficacy and biological effects of the oral proteasome inhibitor ixazomib in diffuse large B-cell lymphoma.

Pham L.V.

Oncotarget 9:346-360(2018).

Characterization of human cancer cell lines by reverse-phase protein arrays.

Liang H.

Cancer Cell 31:225-239(2017).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

Subtype-specific addiction of the activated B-cell subset of diffuse large B-cell lymphoma to FOXP1.

Tucker H.O.

Proc. Natl. Acad. Sci. U.S.A. 113:E577-E586(2016).

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.

O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.

J. Virol. 89:713-729(2015).

MCL1 is deregulated in subgroups of diffuse large B-cell lymphoma.";

Hernandez-Ilizaliturri F.J., Tzankov A., Lenz G.

Leukemia 27:1381-1390(2013).

Genetic heterogeneity of diffuse large B-cell lymphoma.";

Dunson D.B., Dave S.S.

Proc. Natl. Acad. Sci. U.S.A. 110:1398-1403(2013).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.

Kutok J.L., Shipp M.A.

Blood 116:3268-3277(2010).

A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

Haber D.A.

Cancer Res. 70:2158-2164(2010).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Expression of the ULBP ligands for NKG2D by B-NHL cells plays an important role in determining their susceptibility to rituximab-induced ADCC.

Mori F., Ding J.-M., Komatsu H., Iida S., Ueda R.

Int. J. Cancer 125:212-221(2009).

Copy number abnormalities, MYC activity, and the genetic fingerprint of normal B cells mechanistically define the microRNA profile of diffuse large B-cell lymphoma.

Robetorye R.S., Aguiar R.C.T.

Blood 113:6681-6690(2009).

Phorbol ester-induced, cell-cycle-specific, growth inhibition of human B-lymphoma cell lines.

Beckwith M., Longo D.L., O'Connell C.D., Moratz C.M., Urba W.J.

J. Natl. Cancer Inst. 82:501-509(1990).

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