HuTu 80Homo sapiens (Human)Cancer cell line

Also known as: Hutu80, HuTu80, HUTU80, Hutu-80, HUTU-80, HuTu-80, Hutu 80, HUTU 80

🤖 AI SummaryBased on 13 publications

Quick Overview

Human colon cancer cell line with potential for research in drug sensitivity and genetic mutations.

Detailed Summary

The HuTu 80 cell line is a human-derived cell line established from a colon tumor. It is commonly used in cancer research to study tumor biology, drug responses, and genetic mutations. This cell line has been utilized in studies related to colorectal cancer, including investigations into molecular mechanisms and therapeutic strategies. Research involving HuTu 80 has contributed to understanding the genetic and molecular characteristics of colorectal tumors, particularly in the context of drug resistance and targeted therapies. The cell line is also noted for its utility in assessing the efficacy of various chemotherapeutic agents and in exploring the role of specific genetic alterations in tumor progression.

Research Applications

Cancer ResearchDrug Sensitivity StudiesGenetic Mutations AnalysisMolecular Mechanisms of Tumor Progression

Key Characteristics

Human-derivedColon tumor originUsed in drug response studiesRelevant for colorectal cancer research

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1301
Species	Homo sapiens (Human)
Tissue Source	Small intestine, duodenum[UBERON:UBERON_0002114]

Donor Information

Age	53
Age Category	Adult
Sex	Male
Race	caucasian

Disease Information

Disease	Duodenal adenocarcinoma
Lineage	Bowel
Subtype	Duodenal Adenocarcinoma
OncoTree Code	DA

DepMap Information

Source Type	ATCC
Source ID	ACH-000538_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	CTNNB1	p.Ser37Phe (c.110C>T)	Heterozygous	-	Unknown

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

11,13

D13S317

8,11

D16S539

10,11

D18S51

14,17

D19S433

13,15.2

D21S11

31,32.2

D2S1338

17,21

D3S1358

15,17

D5S818

12,13

D7S820

9,11

D8S1179

FGA

21,23

Penta D

2.2

Penta E

12,18

TH01

TPOX

9,11

vWA

16,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Golub T.R., Root D.E., Hahn W.C.

Sci. Data 1:140035-140035(2014).

DOI PubMed PMC

Highly expressed genes in rapidly proliferating tumor cells as new targets for colorectal cancer treatment.

Sanchez A., Schwartz S. Jr., Bilic J., Mariadason J.M., Arango D.

Clin. Cancer Res. 21:3695-3704(2015).

DOI PubMed

The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.

Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.

Nat. Commun. 6:7002.1-7002.10(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Human tumor cell strains defective in the repair of alkylation damage.

Mattern M.R.

Carcinogenesis 1:21-32(1980).

DOI PubMed

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Repair of O6-methylguanine in DNA by demethylation is lacking in Mer- human tumor cell strains.

Yarosh D.B., Foote R.S., Mitra S., Day R.S. 3rd

Carcinogenesis 4:199-205(1983).

DOI PubMed

Relationship between karyotype of tissue culture lines and tumorigenicity in nude mice.

Gershwin M.E., Lentz D., Owens R.B.

Exp. Cell Biol. 52:361-370(1984).

DOI PubMed

Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains.

Lubiniecki A.S., Girardi A.J., Galloway S.M., Bynum G.D.

Nature 288:724-727(1980).

DOI PubMed

Polymorphic enzyme analysis of cultured human tumor cell lines.";

Dracopoli N.C., Fogh J.

J. Natl. Cancer Inst. 70:469-476(1983).

PubMed

Human tumor lines for cancer research.";

Fogh J.

Cancer Invest. 4:157-184(1986).

DOI PubMed

Absence of HeLa cell contamination in 169 cell lines derived from human tumors.

Fogh J., Wright W.C., Loveless J.D.

J. Natl. Cancer Inst. 58:209-214(1977).

DOI PubMed

One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.

Fogh J., Fogh J.M., Orfeo T.

J. Natl. Cancer Inst. 59:221-226(1977).

DOI PubMed

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