IA-LMHomo sapiens (Human)Cancer cell line
Also known as: IALM
🤖 AI SummaryBased on 3 publications
Quick Overview
Human cell line for cancer research
Detailed Summary
The IA-LM cell line is a human-derived cell line used in cancer research. It is part of the Cancer Cell Line Encyclopedia (CCLE) and the Catalogue of Somatic Mutations in Cancer (COSMIC) databases. These resources provide extensive genomic and pharmacological data, enabling researchers to study drug sensitivity and genetic predictors of cancer treatment responses. The cell line is utilized in studies involving genomic profiling, drug screening, and understanding the molecular mechanisms of cancer. Its inclusion in large-scale studies allows for the exploration of genetic diversity and its impact on cancer biology and therapeutic outcomes.
Research Applications
Genomic profilingDrug screeningCancer biology research
Key Characteristics
Part of CCLE and COSMIC databasesUsed for studying drug sensitivityUtilized in molecular mechanism studies
Generated on 6/16/2025
Basic Information
| Database ID | CVCL_1302 |
|---|---|
| Species | Homo sapiens (Human) |
Donor Information
| Age | 68 |
|---|---|
| Age Category | Adult |
| Sex | Male |
| Race | asian |
Disease Information
| Disease | Lung large cell carcinoma |
|---|---|
| Lineage | Lung |
| Subtype | Large Cell Lung Carcinoma |
| OncoTree Code | LCLC |
DepMap Information
| Source Type | RIKEN |
|---|---|
| Source ID | ACH-000672_source |
Known Sequence Variations
| Type | Gene/Protein | Description | Zygosity | Note | Source |
|---|---|---|---|---|---|
| MutationSimple | TP53 | p.Gln192Ter (c.574C>T) | Unspecified | - | PubMed=28273451, PubMed=22931248 |
| MutationSimple | KRAS | p.Gly12Cys (c.34G>T) | Unspecified | - | PubMed=21173094 |
Haplotype Information (STR Profile)
Short Tandem Repeat (STR) profile for cell line authentication.
Amelogenin
X
CSF1PO
10
D13S317
8
D16S539
10,11
D5S818
10,11
D7S820
8,12
TH01
9
TPOX
8
vWA
18,19
Gene Expression Profile
Gene expression levels and statistical distribution
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Full DepMap dataset with combined data across cell lines
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Publications
Genetic diversity among the present Japanese population: evidence from genotyping of human cell lines established in Japan.
Kasai F., Fukushima M., Miyagi Y., Nakamura Y.
Hum. Cell 37:944-950(2024).
Pan-cancer proteomic map of 949 human cell lines.";
Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Cancer Cell 40:835-849.e8(2022).
Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
Sellers W.R., Gygi S.P.
Cell 180:387-402.e16(2020).
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Sellers W.R.
Nature 569:503-508(2019).
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
Cancer Res. 79:1263-1273(2019).
A landscape of pharmacogenomic interactions in cancer.";
Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
Cell 166:740-754(2016).
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
Nature 483:603-607(2012).