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IGR-1Homo sapiens (Human)Cancer cell line

Also known as: Institut Gustave Roussy-1, IGR1, IGR 1

🤖 AI SummaryBased on 9 publications

Quick Overview

IGR-1 is a human melanoma cell line used in cancer research.

Detailed Summary

IGR-1 is a human melanoma cell line derived from a primary tumor. It is known for its ability to produce melanin and has been used in studies related to melanin synthesis and tyrosinase activity. The cell line has been characterized for its morphological and biochemical properties, including the presence of melanosomes and the expression of specific markers such as 5-S-cysteinyldopa. Research on IGR-1 has contributed to understanding the mechanisms of melanogenesis and the role of tyrosinase in melanin production. It has also been used in studies examining the effects of various treatments on melanoma cells, including the response to drugs and the impact of culture conditions on cell behavior.

Research Applications

Melanin synthesis studiesTyrosinase activity analysisMelanoma cell behavior in cultureDrug response studies

Key Characteristics

Production of 5-S-cysteinyldopaPresence of melanosomesExpression of tyrosinaseMorphological changes in culture

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1303
Species	Homo sapiens (Human)
Tissue Source	Inguinal lymph node[UBERON:UBERON_0001542]

Donor Information

Age	42
Age Category	Adult
Sex	Male

Disease Information

Disease	Cutaneous melanoma
Lineage	Skin
Subtype	Melanoma
OncoTree Code	MEL

DepMap Information

Source Type	DSMZ
Source ID	ACH-000882_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	RAC1	p.Pro29Ser (c.85C>T)	Heterozygous	-	PubMed=25056119
MutationSimple	BRAF	p.Val600Lys (c.1798_1799delGTinsAA)	Heterozygous	-	from parent cell line YUSIT1

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

X,Y

CSF1PO

10

D13S317

13

D16S539

11

D18S51

14,16

D19S433

15,16

D21S11

32.2

D2S1338

20,22

D3S1358

14,17

D5S818

10,11

D7S820

10,11

D8S1179

10

FGA

23,24

Penta D

10

Penta E

7,11

TH01

7,9.3

TPOX

8

vWA

17,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

The RAC1 P29S hotspot mutation in melanoma confers resistance to pharmacological inhibition of RAF.

Davies M.A., Mills G.B., Chin L.

Cancer Res. 74:4845-4852(2014).

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

Immunocytochemical analysis of cell lines derived from solid tumors.

Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.

J. Histochem. Cytochem. 49:1369-1378(2001).

Tumorigenicity of human malignant melanocytes in nude mice in relation to their differentiation in vitro.

Aubert C., Rouge F., Galindo J.-R.

J. Natl. Cancer Inst. 64:1029-1040(1980).

Cytoenzymological caracterization of cells from human skin melanoma in culture.

Janiaud P., Le Calvez J., Aubert C.

Ann. Dermatol. Syphiligr. (Paris) 100:536-539(1973).

Melanin-related biochemistry of IGR 1 human melanoma cells.";

Karg E., Odh G., Rosengren E., Wittbjer A., Rorsman H.

Melanoma Res. 1:5-13(1991).

Catechols in primary and metastatic human malignant melanoma cells in monolayer culture.

Aubert C., Lagrange C., Rorsman H., Rosengren E.

Eur. J. Cancer 12:441-445(1976).

Cellular localization of tyrosinase in human malignant melanoma cell lines.

Foa C., Aubert C.

J. Invest. Dermatol. 68:369-378(1977).