IPC-298Homo sapiens (Human)Cancer cell line

Also known as: IPC298, IPC 298

🤖 AI SummaryBased on 8 publications

Quick Overview

IPC-298 is a human cell line derived from a melanoma tumor, used in cancer research for studying genetic mutations and drug res...

Detailed Summary

IPC-298 is a human melanoma cell line utilized in cancer research to investigate genetic mutations and their impact on drug responses. It is part of a comprehensive panel of cell lines used to identify clinically relevant mutations and understand tumor biology. This cell line has been analyzed for its genetic profile, including mutations in genes such as BRAF and NRAS, which are critical in melanoma development. Research involving IPC-298 contributes to the development of targeted therapies and understanding of cancer progression.

Research Applications

Cancer researchGenetic mutation analysisDrug response studies

Key Characteristics

Melanoma-derivedBRAF and NRAS mutationsUsed in targeted therapy development

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1307
Species	Homo sapiens (Human)

Donor Information

Age	64
Age Category	Adult
Sex	Female

Disease Information

Disease	Cutaneous melanoma
Lineage	Skin
Subtype	Cutaneous Melanoma
OncoTree Code	SKCM

DepMap Information

Source Type	DSMZ
Source ID	ACH-000915_source

Known Sequence Variations

Type	Gene/Protein	Description	Zygosity	Note	Source
MutationSimple	TP53	p.Arg213Ter (c.637C>T)	Unspecified	-	Unknown
MutationSimple	TERT	c.1-146C>T (c.250C>T) (C250T)	Unspecified	In promoter	PubMed=31068700
MutationSimple	NRAS	p.Gln61Leu (c.182A>T)	Unspecified	-	PubMed=26214590
MutationSimple	CDKN2A	p.Arg99Pro (c.296G>C)	Homozygous	-	Unknown, Unknown, PubMed=9354451

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

10,12

D13S317

D16S539

12,14

D18S51

D19S433

14,15

D21S11

29,31

D2S1338

17,20

D3S1358

D5S818

10,11

D7S820

11,12

D8S1179

13,15

FGA

23,24

Penta D

11,14

Penta E

5,10

TH01

6,9

TPOX

10,12

vWA

18,22

Gene Expression Profile

Gene expression levels and statistical distribution

Loading cohorts...

Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Quantitative proteomics of the Cancer Cell Line Encyclopedia.";

Sellers W.R., Gygi S.P.

Cell 180:387-402.e16(2020).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Loewer M., Sahin U., Castle J.C.

Genome Med. 7:118.1-118.7(2015).

DOI PubMed PMC

A resource for cell line authentication, annotation and quality control.

Neve R.M.

Nature 520:307-311(2015).

DOI PubMed

A comprehensive transcriptional portrait of human cancer cell lines.

Settleman J., Seshagiri S., Zhang Z.-M.

Nat. Biotechnol. 33:306-312(2015).

DOI PubMed

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

A high-throughput panel for identifying clinically relevant mutation profiles in melanoma.

Scolyer R.A., Mann G.J., Schmidt C.W., Herington A., Hayward N.K.

Mol. Cancer Ther. 11:888-897(2012).

DOI PubMed

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Immunocytochemical analysis of cell lines derived from solid tumors.

Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.

J. Histochem. Cytochem. 49:1369-1378(2001).

DOI PubMed

CDKN2A/p16 is inactivated in most melanoma cell lines.";

Gabrielli B.G., Parsons P.G., Hayward N.K.

Cancer Res. 57:4868-4875(1997).

PubMed

Establishment and characterization of human ocular melanoma cell lines.

Aubert C., Rouge F., Reillaudou M., Metge P.

Int. J. Cancer 54:784-792(1993).

DOI PubMed