IST-Mes1Homo sapiens (Human)Cancer cell line

Also known as: Istituto Scientifico Tumori-Mesothelioma 1, ISTMES1, IST-MES-1, IST-MES1

🤖 AI SummaryBased on 4 publications

Quick Overview

Human mesothelioma cell line for cancer research.

Detailed Summary

IST-Mes1 is a human mesothelioma cell line established from pleural effusions. It exhibits a slow proliferation rate and pleomorphic changes during culture. The cell line expresses mesothelial markers such as cytokeratins 8 and 18, vimentin, and the mesothelial antigen HMBE-1, but does not express carcinomyogenic antigens. It shows abnormal karyotypes with common chromosomal abnormalities, including monosomy 17 and structural deletions of 6q. IST-Mes1 secretes interleukin-6 (IL-6) and transforming growth factor-beta (TGF-β) and can respond to lipopolysaccharide (LPS) by releasing tumor necrosis factor-alpha (TNF-α). Additionally, it expresses the SV40 large T antigen (Tag) in a subset of cells, suggesting potential implications for immunotherapy strategies.

Research Applications

Cancer researchImmunotherapy studiesGenetic and cytogenetic analysis

Key Characteristics

Expresses mesothelial markersAbnormal karyotypes with chromosomal deletionsSecretes pro-inflammatory cytokinesSV40 Tag expression in a subset of cells

Generated on 6/16/2025

Basic Information

Database ID	CVCL_1311
Species	Homo sapiens (Human)
Tissue Source	Pleural effusion[UBERON:UBERON_0000175]

Donor Information

Age	70
Age Category	Adult
Sex	Female
Race	caucasian

Disease Information

Disease	Pleural mesothelioma
Lineage	Pleura
Subtype	Pleural Mesothelioma, Epithelioid Type
OncoTree Code	PLEMESO

DepMap Information

Source Type	ICLC
Source ID	ACH-000569_source

Haplotype Information (STR Profile)

Short Tandem Repeat (STR) profile for cell line authentication.

Amelogenin

CSF1PO

10,11

D13S317

D16S539

D5S818

11,12

D7S820

8,10

TH01

TPOX

vWA

17,18

Gene Expression Profile

Gene expression levels and statistical distribution

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Full DepMap dataset with combined data across cell lines

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Publications

Pan-cancer proteomic map of 949 human cell lines.";

Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.

Cancer Cell 40:835-849.e8(2022).

DOI PubMed PMC

Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.

van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.

Nat. Commun. 10:3574.1-3574.11(2019).

DOI PubMed PMC

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Sellers W.R.

Nature 569:503-508(2019).

DOI PubMed PMC

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

Cancer Res. 79:1263-1273(2019).

DOI PubMed PMC

A landscape of pharmacogenomic interactions in cancer.";

Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.

Cell 166:740-754(2016).

DOI PubMed PMC

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

Nature 483:603-607(2012).

DOI PubMed PMC

Signatures of mutation and selection in the cancer genome.";

Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.

Nature 463:893-898(2010).

DOI PubMed PMC

Establishment of four new mesothelioma cell lines: characterization by ultrastructural and immunophenotypic analysis.

Mutti L.

Eur. Respir. J. 13:527-534(1999).

DOI PubMed